Construction and Functional Properties of Multifunctional Chitosan Hydrogel
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Construction and Functional Properties of Multifunctional Chitosan Hydrogel Fei Lianga,*, Jing Zhaob, and Chunyu Dengb aDepartment
of Pharmacy and Shaanxi Key Laboratory of Brain Disorders and Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi’an Medical University, Xi’an, 710021 China b School of Environmental and Chemical Engineering, Xi’an Polytechnic University, Xi’an, 710048 China *e-mail: [email protected] Received March 26, 2020; revised May 4, 2020; accepted May 9, 2020
Abstract—Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this work, chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier, temperature sensitive N-isopropylacrylamide (NIPAm) and pH sensitive 2-acrylamido-2-methylpropane (AMPS) as monomers. The adsorption and drug release properties of chitosan hydrogel are discussed emphatically.The adsorption performance of chitosan hydrogel on copper ions showed that the temperature and the concentration of copper ions had influence on the adsorption. When the concentration of copper ions was 800 mg/L at 25°C, the equilibrium adsorption capacity was 225.8 mg/g, quasi-second order kinetic equation was suitable for describing the adsorption process. With the methylene blue as the drug model, the controlled release results showed that the temperature and the initial drug dosage had great effect on controlled release performance, and the cumulative release rate of 48 h was about 70%, which could achieve sustained release and controlled release to a certain extent.The experimental results also showed that the chitosan hydrogel can be completely degraded for about 20 days with excellent degradation performance. In conclusion, chitosan hydrogel has broad application prospects in drug controlled release, tissue engineering, environmental engineering and so on. DOI: 10.1134/S0965545X20050120
INTRODUCTION Naturally derived biomaterials designed for environmental protection, tissue engineering and drug release applications have become increasingly safer and more multifunctional [1]. Hydrogels, especially environmentally stimuli-sensitive hydrogels based on natural polymers have attracted a great deal of interest, owing to its unique properties, such as good biocompatibility, hydrophilicity, similar to the biological soft tissue and so on [2, 3]. Stimuli-sensitive hydrogels which are responsive to various stimuli such as temperature, pH, light, electricity and magnetism can be used to develop smart multifunctional biomaterials that are sensitive to specific molecular or biomolecular stimuli [4–6]. As three-dimensional network of porous polymer materials, hydrogels contain a large number of –NH2, –OH, –COOH and other active groups, which can be adsorbent materials to remove heavy metal ions of wastewater effectively by adsorbing metal cations by chelate,
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