Contrast enhancement imaging in coronary arteries in patients with systemic lupus erythematosus
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POSTER PRESENTATION
Open Access
Contrast enhancement imaging in coronary arteries in patients with systemic lupus erythematosus Valentina O Puntmann1*, David D’Cruz2, Peter Taylor3, Tarique Hussain1, Andreas Indermuehle1, Britta Butzbach1, Rene M Botnar1, Eike Nagel1 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary Patients with SLE suffer from accelerated atherosclerosis due to systemic inflammation. We examined subclinical coronary artery involvement in patients with systemic lupus erythematous (SLE) by contrast enhanced inversion recovery (CE-IR) coronary magnetic resonance imaging. Background Vessel wall inflammation plays a key role in the initiation and progression of atherosclerosis, from endothelial injury to remodeling and plaque formation. Cardiovascular (CV) magnetic resonance (CMR) provides noninvasive visualization and characterization of arterial remodeling both in the great vessels, and also the coronary arteries. Contrast-enhanced inversion-recovery (CEIR) prepared coronary imaging allows detection of vessel wall enhancement by visualization of contrast agent uptake. We examined subclinical coronary artery involvement in patients with systemic lupus erythematous (SLE) by contrast enhanced inversion recovery (CE-IR) coronary magnetic resonance imaging. Methods In 19 SLE patients in stable remission (male, n=4), we performed CE-IR magnetic resonance coronary imaging 40 minutes after administration of gadolinium contrast agents. Contrast-to-noise ratio (CNR) within the coronary artery and ascending aortic vessel wall was quantified and compared to age and gender-matched apparently healthy controls (n=9). 1 Cardiovascular Imaging, King’s College London, London, UK Full list of author information is available at the end of the article
Results Results. There was a significant increase in mean coronary CNR in SLE patients (SLE vs. controls: 7.7±2 vs. 3.9 ±0.9, p
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