Control Mechanisms of Drinking
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Mechanisms of Drinking Edited by
G. Peters J. T. Fitzsimons L. Peters-Haefeli
With 136 Figures
Springer-Verlag Berlin Heidelberg New York 1975
This book is sponsored by the International Commission on the Physiology of Food and Fluid Intake, an agency of the International Union of Physiological Sciences
ISBN-13: 978-3-642-61909-0
e-ISBN-13: 978-3-642-61907-6
DOl: 10.1007/978-3-642-61907-6 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than'private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. The use of registered names, trademarks, etc in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. © by Springer-Verlag Berlin' Heidelberg 1975. Library of Congress Catalog Card Number 74-9101. Softcover reprint of the hardcover 1st edition 1975
Preface
Practically all the chapters in this volume contain new and previously unpublished research reports and reviews on the physiological mechanisms which induce drinking of non-nutritive fluids. Though based on a Symposium on Thirst we have not called the volume by this title because thirst as such, a subjective human sensation, is not in fact discussed in these pages. The main section headings in the list of contents give an idea of the topics dealt with and it is evident from these that a large number of contributions deal with the possible role of the renin-angiotensin system in the control of water intake. One difficulty until now in accepting the suggestion that this system could act as a mediator between the vascular system and cerebral receptors in extracellular thirst, was the fairly large doses of renin or of angiotensin which had to be injected peripherally in order to induce drinking. One contributor to this volume shows that the dose of angiotensin II required is in fact much smaller than previously reported and that this dose is within a physiologically possible range. Another difficulty arises from the fact that angiotensin and similar pep tides cannot be expected to cross the blood-brain barrier. Again, observations described in this volume suggest that the receptors for angiotensin-induced drinking could be located in the walls of the ventricular system, possibly in the subfornical organ, and that angiotensin may cross the blood-CSF barrier. The question of the relationship between the cerebral and the renal renin-angiotensin systems was very much in the minds of all and there is no satisfactory resolution of this problem at
present. It is possible that the cerebral system has a neurotransmitter role, especially as intracerebral angiotensin-induced
