Coordinating Organismal Physiology Through the Unfolded Protein Response

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling criti

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R. Luke Wiseman · Cole M. Haynes Editors

Coordinating Organismal Physiology Through the Unfolded Protein Response

Current Topics in Microbiology and Immunology Volume 414

Series editors Rafi Ahmed School of Medicine, Rollins Research Center, Emory University, Room G211, 1510 Clifton Road, Atlanta, GA 30322, USA Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany Arturo Casadevall W. Harry Feinstone Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E5132, Baltimore, MD 21205, USA Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA Adolfo Garcia-Sastre Icahn School of Medicine at Mount Sinai, Department of Microbiology, 1468 Madison Ave., Box 1124, New York, NY 10029, USA Akiko Iwasaki Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street TAC S655B, New Haven, CT 06520, USA Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906 13288, Marseille Cedex 9, France Klaus Palme Institute of Biology II/Molecular Plant Physiology, Albert-Ludwigs-Universität Freiburg, Freiburg, 79104, Germany Rino Rappuoli GSK Vaccines, Via Fiorentina 1, Siena, 53100, Italy

Honorary editors Michael B. A. Oldstone Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA

More information about this series at http://www.springer.com/series/82

R. Luke Wiseman Cole M. Haynes •

Editors

Coordinating Organismal Physiology Through the Unfolded Protein Response Responsible series editor: Peter K. Vogt

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Editors R. Luke Wiseman Department of Molecular Medicine The Scripps Research Institute La Jolla, CA USA

Cole M. Haynes Department of Molecular, Cell, and Cancer Biology University of Massachusetts Medical School Worcester, MA USA

ISSN 0070-217X ISSN 2196-9965 (electronic) Current Topics in Microbiology and Immunology ISBN 978-3-319-78529-5 ISBN 978-3-319-78530-1 (eBook) https://doi.org/10.1007/978-3-319-78530-1 Library of Congress Control Number: 2018939014 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer soft