Endurance training in mice increases the unfolded protein response induced by a high-fat diet
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ORIGINAL PAPER
Endurance training in mice increases the unfolded protein response induced by a high-fat diet Louise Deldicque & Patrice D. Cani & Nathalie M. Delzenne & Keith Baar & Marc Francaux
Received: 19 September 2011 / Accepted: 27 July 2012 / Published online: 9 August 2012 # University of Navarra 2012
Abstract Certain conditions, such as several weeks of high-fat diet, disrupt endoplasmic reticulum (ER) homeostasis and activate an adaptive pathway referred as the unfolded protein response. When the unfolded protein response fails, the result is the development of inflammation and insulin resistance. These two pathological states are known to be improved by regular exercise training but the mechanisms remain largely undetermined. As it has recently been shown
L. Deldicque (*) Research Centre for Exercise and Health, Department of Biomedical Kinesiology, K.U. Leuven, Tervuursevest 101, Box 1500, 3001 Leuven, Belgium e-mail: [email protected] L. Deldicque : M. Francaux Institute of Neurosciences, Research Group in Muscle Exercise and Physiology, Université Catholique de Louvain, Place Pierre de Coubertin, 1, 1348 Louvain-la-Neuve, Belgium P. D. Cani : N. M. Delzenne Louvain Drug Research Institute, Metabolism and Nutrition research group, Université Catholique de Louvain, Avenue E. Mounier, 73, PMNT 73/69, 1200 Brussels, Belgium K. Baar Department of Neurobiology, Physiology and Behavior, University of California Davis, One Shields Avenue, 181 Briggs Hall, Davis, CA 95616, USA
that the unfolded protein response is regulated by exercise, we hypothesised that concomitant treadmill exercise training (HFD+ex) prevents ER homeostasis disruption and its downstream consequences induced by a 6-week high-fat diet (HFD) in mice by activating the protective unfolded protein response. Several welldocumented markers of the unfolded protein response were measured in the soleus and tibialis anterior muscles as well as in the liver and pancreas. In HFD mice, an increase in these markers was observed (from 2- to 15-fold, P < 0.05) in all tissues studied. The combination of HFD+ex increased the expression of several markers further, up to 100 % compared to HFD alone (P
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