Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats
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Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats Hua-Pin Wang • Ching-Wen Liu • Hsueh-Wen Chang Jen-Wei Tsai • Ya-Zhu Sung • Li-Ching Chang
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Received: 1 August 2012 / Accepted: 19 November 2012 / Published online: 27 November 2012 Ó Springer Science+Business Media Dordrecht 2012
Abstract Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia–reperfusion (I/R) sequence by analyzing the influence on stromal cellderived factor-1a (SDF-1a and chemokine (C-X-C motif) receptor 4 (CXCR4) expressions and senescence during recovery. Chemokine SDF-1 [now called chemokine C-X-C motif ligand 12 (CXCL12)] and its receptor CXCR4 are crucial in kidney repair after ischemic acute renal failure. CS treatment significantly alleviated I/R-induced renal damage assessed by creatinine levels (p \ 0.05) and abated renal tubular damages assessed by periodic acid-Schiff with diastase (PASD) staining. CS induced early SDF-1a expression and increased CXCR4 expression 1–6 h postreperfusion. Histology studies have revealed that CS induced
H.-P. Wang Y.-Z. Sung Division of Urology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan C.-W. Liu School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan H.-W. Chang Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan J.-W. Tsai Department of Pathology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan L.-C. Chang (&) Department of Occupational Therapy, I-Shou University, Kaohsiung, Taiwan e-mail: [email protected]
SDF-1a in squamous cells of Bowman’s capsule, mesangial cells, distal convoluted tubules (DCT), and proximal convoluted tubules (PCT). CS also improved renal repair in I/Rinduced injury by increasing Ki-67 staining. I/R induced renal senescence after 3 and 6 h of reperfusion. However, CS alleviated I/R-induced senescence at early stage (1 and 3 h). We conclude that CS protects against I/R injury via the SDF1/CXCR4-signaling axis and alleviates senescence. Keywords Cordyceps sinensis Kidney Ischemia/reperfusion SDF-1a CXCR4 Senescence
Introduction Cordyceps sinensis (Berk) Sacc. is a valuable traditional Chinese medicine. Composed of the parasitic Cordyceps fungus and its host, the larva of Hepialus armoricanus Oberthur, Cordyceps sinensis (CS) is a common ingredient of nourishing tonics used to replenish health [1]. Medical research has expanded the uses of CS extracts to stimulating the immune system, inhibiting tumor growth, and treating inflammation and oxidation [2]. CS is extensively used by Chinese physicians to treat chronic renal diseases, including nephritis, renal dysfunction or failure, pyelonephritis, and nephrotic syndrome. Clinical studies have shown that CS-induced functional improvement in renal failure patients significantly coincided with changes in T cell subgroups [3]. These results suggest a possible correlation of CS-mediated renal dysfunction
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