Core Concepts in Renal Transplantation
Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management. Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplan
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Anil Chandraker Ajay K. Singh
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Mohamed H. Sayegh
Editors
Core Concepts in Renal Transplantation
Editors Anil Chandraker, MB, FASN, FRCP Harvard Medical School, Renal Division Brigham and Women’s Hospital Francis Street 75 Boston, MA 02115, USA [email protected]
Mohamed H. Sayegh, MD Harvard Medical School, Renal Division Brigham and Women’s Hospital Francis Street 75 Boston, MA 02115, USA [email protected]
Ajay K. Singh, MB, FRCP(UK) Harvard Medical School, Renal Division Brigham and Women’s Hospital Francis Street 75 Boston, MA 02115, USA [email protected]
ISBN 978-1-4614-0007-3 e-ISBN 978-1-4614-0008-0 DOI 10.1007/978-1-4614-0008-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011941612 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to my parents Khetram and Draupadi Chandraker for all the years of love and support.
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Preface
Over the last few years there have been many changes in the field of transplantation. This book aims to summarize these changes and is meant for both the nephrologist and the nonspecialist with an interest in kidney transplantation. All of the chapters provide up-to-date information on the various aspects of transplantation, from basic immunobiology to medical care of the transplant recipient. The first successful kidney transplant, conducted over 50 years ago, dramatically changed the face of medicine. It helped spur development in the areas of nephrology, immunology, drug development, and surgery. It also helped develop transplantation as a treatment for chronic diseases for other organ systems such as heart, lung, liver, and pancreas among others. Historically, the technical ability to transplant a kidney preceded the ability to suppress the immune response against foreign tissue; in fact the way in which the im
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