Corpuscles Atlas of Red Blood Cell Shapes
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Atlas of Red Blood Cell Shapes
Spri nger-Verlag Berl i n Heidel berg New York 1974
Marcel Bessis Professor, School of Medicine, University of Paris Director, Institut de Pathologie Cellulaire Hopital de Bicetre, Paris, France
With 121 Figures
ISBN-13: 978-3-642-65659-0 e-ISBN-13: 978-3-642-65657-6 DOl: 10.1007/978-3-642-65657-6
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under ยง 54 of the German Copyright Law, where copies are mode for other than private use a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. ((~) by Springer-Verlag Berl in Heidelberg 1974 Library of Congress Catalog Card Number 73-77351 Softcover reprint of the hardcover 1st edition 1974 Composition: William Clowes & Sons Ltd, London Reproduction and printing: Universitatsdruckerei Sturtz, Wurzburg Typeface: Gill, light Paper: BBOT* Scheufelen, Oberlenningen Dust cover and layout designed by J.Tesch, Heidelberg
Preface
The shQpe of Qn erythrocyte is determined by Q delicQte equilibrium of extrinsic Qnd intrinsic forces. It mQY chQnge during mQny PQtholog iCQI stQtes QS well QS du ri ng Q vQriety of experimentQI mQnipulQtions. Correct eVQluQtion of the fine detQi Is of the red cell shQpe thus provides i nformQtion of the g reQtest i mportQnce for the proper i nterpretQtion of the physiology Qnd PQthophysiology of mQny Qnemic stQtes. In eXQmining red cells, the hemQtologist observes Q drop of blood spreQd on Q glQSS slide through the light microscope. This type of eXQminQtion is likely to remQin the routine technique of blood cytology for Q long time to come. Still, we should not forget thQt blood smeQrs Qre QrtifQcts. The smeQring flQttens the cells completely, obliterQting mQny of their chQrQcteristics Qnd distorting others. It is therefore necessQry to conduct Q PQrQllel observQtion of cells in the I ivi ng stQte. The fundQmentQI vQlue of QII such observQtions remQins limited by the resolving power of the light microscope, which provides Q mQximum enlQrgement of one thousQnd times. To be sure, the trQnsm ission electron microscope CQn provide en IQrgements of one mill ion times, but it IQcks penetrQti ng power, so thQt one hQS to section Q cell into five hundred slices before observi ng it. The recent Qdvent of the SCQn n i ng electron m icroscope hQS chQnged the situQtion rQd iCQlly. As with the trQnsmission electron microscope, the cells must be fixed, but they CQn be observed in their three dimensions Qnd revolved before our very eyes, thus providing detQils of the surfQce Qnd the shQpe of cells never before visUQI ized. The initiQI excitement over the new toy triggered Q rush of publicQtions, some of them overenthusiQstic Qnd uncriticQI. Upon eXQminQtion, some of the new QPpeQrQnces of red cells were found to be Qt odds with those p
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