Correction to: Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry
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CORRECTION
Correction to: Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry Andrew Li1,2* and Amartya Mukhopadhyay1,2,3
Correction to: Critical Care (2020) 24:535 https://doi.org/10.1186/s13054-020-03245 -2
achieving positive energy balance. Non-survivors remained hypometabolic despite feeding.
Following publication of the original article [1], the authors reported a misalignment error of the x-axis in Fig. 1b; in addition, there were two typos and two formatting errors. The revised Fig. 1b and revised text is indicated hereafter. The changes have been highlighted in bold typeface.
The sentence currently reads:
The sentence currently reads: The metabolic profiles differed between survivors and non-survivors (Fig. 1a). Both groups had negative energy balance during fasting state. Survivors transitioned to a hypermetabolic state following feeding initiation, achieving positive energy balance. Non-survivors remained hypometabolic despite feeding. The sentence should read: The metabolic profiles differed between survivors and non-survivors (Fig. 1a). Both groups had negative energy balance during fasting state. Survivors transitioned to a hypermetabolic state following feeding initiation,
The original article can be found online at https://doi.org/10.1186/s1305 4-020-03245-2. *Correspondence: [email protected] 1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Full list of author information is available at the end of the article
Our study advances the understanding of energy balance and substrate utilization in sepsis. During fasting, low insulin with elevated counter-regulatory hormones promotes lipolysis; muscle glycogen is depleted at an exponential rate greater than athletes running marathons [4]. The predominant energy substrate switches from carbohydrates to lipids—the hallmark of fasting physiology. This explains the low RQ in early sepsis, when patients are preferentially utilizing lipids (RQ ≤ 0.8) during permissive underfeeding [5]. The hypermetabolic state and inability for non-survivors to transit to carbohydrate utilization suggest ongoing debilitating mitochondrial dysfunction, consistent with associated multi-organ failure [6]. However, whether adjusting the feeding types and regimen to alter these patterns and improve outcomes remain unknown. The sentence should read: Our study advances the understanding of energy balance and substrate utilization in sepsis. During fasting, low insulin with elevated counter-regulatory hormones promotes lipolysis; muscle glycogen is depleted at an exponential rate greater than athletes running marathons [4]. The predominant energy substrate switches from carbohydrates to lipids—the hallmark of fasting physiology. This explains the low RQ in early sepsis, when patients
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction
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