Could the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?
- PDF / 199,653 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 56 Downloads / 198 Views
ORIGINAL ARTICLE
Could the appropriate anti-diabetic therapy be mixed insulin in dialysis patients? Vehbi Demircan 1 Zülfükar Yılmaz 2
Yaşar Yıldırım 2 & Emre Aydın 2 & Ali Veysel Kara 2 & Fatma Yılmaz Aydın 3 2 4 4 & Ali Kemal Kadiroğlu & Alpaslan Kemal Tuzcu & Zafer Pekkolay &
&
Received: 24 May 2020 / Accepted: 28 October 2020 # Research Society for Study of Diabetes in India 2020
Abstract Background A good glycemic regulation should be provided to reduce mortality and morbidity in patients with end-stage renal failure due to diabetes mellitus. However, the use of insulin therapies in patients with renal failure is troublesome due to the increased rate of side effects. In our study, we investigated the frequency of hypoglycemia and its symptoms in patient groups receiving intensive and mixed insulin therapies. Materials and methods This prospective study included 89 hemodialysis patients with DM-related stage 5 chronic kidney disease who were followed up in a nephrology clinic of a university hospital between January 2013 and August 2015. Our study group was divided into two groups as those receiving intensive insulin therapy and mixed insulin therapy. Group 1 and group 2 consisted of 46 patients and 43 patients, respectively. Hypoglycemia (glucose < 70 mg/dl) was investigated in patients with HbA1c levels that decreased below 7% after treatment, and the symptoms were evaluated according to the hypoglycemic scale. The results between the groups were evaluated using chi-square and Student’s t test Results A total of 89 patients were included in the study. HbA1c was 6.83% in the group receiving intensive insulin therapy and 6.95% in the group receiving mixed insulin therapy (p > 0.05). Hypoglycemia was detected in 27 patients (58.7%) in the intensive insulin therapy group and 14 patients (32.6%) in the mixed insulin therapy group. There was a significant level of hypoglycemia in the group receiving intensive insulin therapy (p < 0.05). In our study, the group receiving intensive insulin therapy had higher frequency and severity of common hypoglycemia symptoms such as confusion, sweating, weakness, dysphasia, palpitations, blurred vision, and feeling hungry. Conclusion There was a higher frequency of hypoglycemia under intensive insulin therapy in patients undergoing dialysis due to chronic kidney failure, which suggests that mixed insulin therapy is the ideal treatment to avoid hypoglycemia in this group of patients. Keywords Diabetes mellitus . Hypoglycemia . Insulin therapy . Dialysis . Kidney failure
Background
* Vehbi Demircan [email protected] 1
Department of Haematology—Internal Medicine, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey
2
Department of Nephrology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey
3
Department of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey
4
Department of Endocrinology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey
Type 2 diabetes mellitus is a chronic disease characterized by hyperglycem
Data Loading...
