COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
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ORIGINAL PAPER
COVID‑19 in people living with human immunodeficiency virus: a case series of 33 patients Georg Härter1 · Christoph D. Spinner2 · Julia Roider3,4 · Markus Bickel5 · Ivanka Krznaric6 · Stephan Grunwald6 · Farhad Schabaz7 · Daniel Gillor8 · Nils Postel9 · Matthias C. Mueller10,11 · Markus Müller12 · Katja Römer13 · Knud Schewe14 · Christian Hoffmann14,15 Received: 21 April 2020 / Accepted: 1 May 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Introduction Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. Methods Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. Results Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. Conclusions This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART. Keywords SARS-CoV-2 · COVID-19 · HIV infection · AIDS · Antiretroviral therapy
* Georg Härter [email protected] 1
Medicover Ulm MVZ, Münsterplatz 6, 89073 Ulm, Germany
School of Medicine, Department of Medicine II, Technical University of Munich, University Hospital Klinikum rechts der Isar, Ismaninger Str. 22, 81675 München, Germany
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Sektion Klinische Infektiologie, Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Pettenkoferstrasse 8a, 80336 München, Germany
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German Center for Infection Research (DZIF), Partner site Munich, München, Germany
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Infektiologikum Frankfurt, Stresemannallee 3, D‑60596 Frankfurt am Main, Germany
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Zentrum für Infektiologie Berlin/Prenzelberg, Driesener Str. 11, 10439 Berlin, Germany
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MVZ Karlsplatz München, Karlsplatz 8, 80335 München, Germany
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MVZ Innere Medizin Köln, Hohenstaufenring 59, 50674 Köln, Germany
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Prinzmed, Sendlinger‑Tor‑Platz 8, 80336 München, Germany
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Department of Infection Medicine, Medical Care Center, MVZ Clotten, Berliner Allee 29, 79110 Freiburg, Germany
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Division of Infectious Diseases, Department of Medicine II, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
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Stuttgart, Germany
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Köln, Germany
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ICH Study Center Hamburg, Glockengießerwall 1, 20095 Hamburg, Germany
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University Hospital of Schleswig-Holstein, Campus Kiel, Arnold‑Heller‑Straße 3, 24105 Kiel, Germany
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Introduction On April 27, the number of confirmed worldwide SARSCoV-2 infections has exceeded up to nearly 3 million cases and n
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