Creatine and Creatine Kinase in Health and Disease
Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to ora
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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany
ASSISTANT EDITORS B.B. BISWAS, University of Calcutta, Calcutta, India P. QUINN, King’s College London, London, U.K. Recent Volumes in this Series Volume 31
Intermediate Filaments Edited by Harald Herrmann and J. Robin Harris
Volume 32
alpha-Gal and Anti-Gal: alpha-1,3-Galactosyltransferase, alpha-Gal Epitopes and the Natural Anti-Gal Antibody Edited by Uri Galili and Jos-Luis Avila
Volume 33
Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker
Volume 34
Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller
Volume 35
Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton
Volume 36
Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan
Volume 37
Membrane Dynamics and Domains Edited by P.J. Quinn
Volume 38
Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz
Volume 39
Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas
Volume 40
Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda
Volume 41
Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta
Volume 42
Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris
Volume 43
Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel
Volume 44
Peroxiredoxin Systems Edited by Leopold Flohé and J. Robin Harris
Volume 45
Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini
Volume 46
Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and Markus Wyss
Creatine and Creatine Kinase in Health and Disease Subcellular Biochemistry Volume 46 Edited by
Gajja S. Salomons VU University Medical Center, Amsterdam, The Netherlands
and
Markus Wyss DSM Nutritional Products Ltd., Basel, Switzerland
A C.I.P. Catalogue record for this book is available from the Library of Congress.
ISBN 978-1-4020-6485-2 (HB) ISBN 978-1-4020-6486-9 (e-book) Published by Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. www.springer.com
Printed on acid-free paper
All Rights Reserved © 2007 Springer No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work.
INTERNATIONAL ADVISORY EDITORIAL BOARD R. BITTMAN, Queens College, City University of New York, New York, USA D. DASGUPTA, Saha Institute of Nuclear Physics, Calcutta, India H. ENGELHARDT, Max-Planck-Institute for Biochemistry, Munich, Germany L. FLOHE, MOLISA GmbH, Magdeburg, Germany H. HERRMANN, German Cancer Research Center, He
