Critical Leg Ischaemia Its Pathophysiology and Management
Jean Natali The pathophysiology and management of chronic critical limb -ischaemia (CLI) has always been a problematic area, at least partly because it involves doc tors from a wide range of the traditional medical specialities including vascular surgery
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Critical Leg Ischaemia Its Pathophysiology and Management Edited by John A. Dormandy and Gunter Stock
With 27 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong
John A. Dormandy Department of Vascular Surgery St. George's Hospital and Medical School London, England
Gunter Stock Research Laboratories ScheringAG, Berlin Federal Republic of Germany
ISBN-13: 978-3-642-75627-6 e-ISBN-13: 978-3-642-75625-2 DOl: 10.1007/978-3-642-75625-2 Library of Congress Cataloging·in·Publication Data Critical leg ischaemia: its pathophysiology and management/edited by John A. Dormandy and Giinter Stock. p.cm. ISBN 0·387-52462-2 (U. S. alk. paper) 1. Peripheral vascular diseases. 2. Leg - Blood-vessels - Diseases. 3. Ischemia. 1. Dormandy, J. A. II. Stock, G. (Gunter) [DNLM: 1. Ischemia - management. 2. Ischemia - physiopathology. 3. Leg - blood supply. WE 850C934j RC694.C75 1990 617.5'8-dc20 DNLM/DLC This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9,1965, in its version of June 24,1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1990 Softcover reprint ofthe hardcover 1st edition 1990 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting, printing and bookbinding: BriihIsche Universitatsdruckerei, Giessen 2125/3020-543210 - Printed on acid-free paper
Preface Jean Natali
The pathophysiology and management of chronic critical limb -ischaemia (CLI) has always been a problematic area, at least partly because it involves doctors from a wide range of the traditional medical specialities including vascular surgery, angiology, diabetology, haematology and radiology. The treatment of these patients also varies largely with local circumstances and national traditions. CLI therefore seemed a particularly appropriate subject for a new type of European consensus approach. In 1988 a series of small workshops were held by the European Working Group on Critical Limb Ischaemia to discuss the definition, pathophysiology, investigation and management of this condition. The process culminated in a meeting in Berlin in March, 1989 where 120 specialists from sixteen European countries, representing the basic
