Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat
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ORIGINAL ARTICLE
Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat Min Lei,1,6 Chunhua Guo,2 Limei Hua,3 Sujuan Xue,1 Dan Yu,1 Chunhua Zhang,4 and Dawei Wang5
Abstract—Osteoarthritis is the most prevalent form of arthritis, affecting a large part of popula-
tion. It has been reported that muscle weakness and inflammation contribute to osteoarthritis development and progression. Oxidative stress plays important roles in muscle dysfunction and inflammation induction. Crocin, a component of saffron, has excellent antioxidative property. However, it is unclear if crocin can be a potential medicine for osteoarthritis therapy. Osteoarthritis in rats was induced by meniscectomy (MNX) surgery. Then, rats were given with 30 mg/ kg of crocin daily for 10 days after osteoarthritis induction. The parameters were determined 7 days after crocin administration. MNX surgery induced osteoarthritis in rats. Crocin treatment significantly decreased osteoarthritis-associated joint pain, decreased muscular interleukin-6 (IL-6) level, and increased citrate synthase (CS) activity, as well as myosin heavy chain (MHC) IIα expression. In addition, crocin reduced muscular lipid peroxidation (LPO) and Nrf2 expression and increased glutathione production and glutathione peroxidase activity. Finally, crocin inhibited the activity of JNK, but not ERK, to repress NF-κB activation and inflammation induction. Crocin attenuates osteoarthritis symptoms through alleviating oxidative stress and inflammation, suggesting that crocin is a potential medicine for osteoarthritis therapy. KEY WORDS: osteoarthritis; oxidative stress; muscle dysfunction; crocin; JNK.
1
Department of Nutrition and Diet, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei Province 050051, China 2 Department of Orthopedics, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei Province 050051, China 3 Department of Nutrition, Bethune International Heping Hospital, No. 398 Zhongshan West Road, Shijiazhuang, Hebei Province 050082, China 4 Department of Emergency Medicine, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei Province 050051, China 5 Department of Oral and Maxillofacial surgery, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei Province 050051, China 6 To whom correspondence should be addressed at Department of Nutrition and Diet, the Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei Province 050051, China. E-mail: [email protected]
INTRODUCTION Osteoarthritis is the most common joint disease, characterized by progressive loss and destruction of articular cartilage, variable degrees of inflammation of the synovium, etc. [1]. Osteoarthritis affects more than 15% of population and is caused by multi-factories, including joint injury, obesity, aging, and so on [2]. However, the detailed molecular mechanisms underlying of osteoarthritis is poorly understood
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