Curcumin-Loaded Electrospun Fibers: Fluorescence and Antibacterial Activity
- PDF / 4,332,543 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 77 Downloads / 249 Views
RESEARCH ARTICLE
Curcumin‑Loaded Electrospun Fibers: Fluorescence and Antibacterial Activity Mário César Albuquerque de Oliveira1 · Fernando Antonio Gomes da Silva Jr.1 · Mateus Matiuzzi da Costa1 · Nikifor Rakov1 · Helinando Pequeno de Oliveira1 Received: 11 April 2020 / Accepted: 9 June 2020 © Donghua University, Shanghai, China 2020
Abstract The health benefits and sensing applications of curcumin-based systems depend on their prevailing photophysical and chemical properties at a specific environment—the characteristic low solubility of curcumin in water hinders high-dosage based applications. To circumvent this drawback, curcumin has been incorporated in hydrophobic environments in nanoscale. Herein, electrospun fibers of Eudragit L100 were loaded with curcumin and applied in fluorescence and antibacterial assays to evaluate prevailing physical and chemical properties in solid-state. The characteristic high loading degree of curcumin (250 mg/mL in Eudragit L100 solution) preserves not only the photophysical properties of molecules (such as the intrinsic fluorescence) but also the antibacterial activity of released molecules from electrospun fibers, characterizing an important strategy for improvement in the applicability potential of natural materials. Keywords Curcumin · Fluorescence · Electrospinning · Hydrophobic core
Introduction Curcumin is a polyphenolic flavonoid (yellow pigment) isolated from the rhizome of the Curcuma longa Linne (commonly applied in Asian cuisine) with a broad range of applications in different fields such as photodynamic therapy [1] and pharmaceutical area, with strong activity in the labeling of amyloid-beta plaques [2] and as antibacterial, antifungal, antiviral [3–10] and wound healing agent [11]. On the other hand, the increasing resistance of bacteria against antibiotics is a direct consequence of the unregulated use of antibiotics in agriculture and farming [12–15]. Natural materials have been considered as adjuvants in treatments against infections [16] being associated with conventional antibiotics [17]. The extensive traditional use of curcumin (against different ailments as a household remedy) is favored by medicinal benefits associated with low side effects (pharmacologically safe) at relatively high nontoxic doses [3, 8]. Anti-carcinogenic effects are relevant since the nanoencapsulation of curcumin enhances the biologic activity of isolated molecules * Helinando Pequeno de Oliveira [email protected] 1
Institute of Materials Science, Federal University of Sao Francisco Valley, Juazeiro, BA 48920‑310, Brazil
[18]. Also, photochemical properties of curcumin favor plenty of photodynamic therapy-related applications, while the study of fluorescence of curcumin represents an important and complex topic to be addressed [19] since it depends on the combination of factors such as polar solvent degree, pH and concentration [20, 21]. Besides, curcumin potentiates the antibacterial activity of conventional antibiotics such as cefixime, cefotaxime, vancomyci
Data Loading...
