Current application of cannabidiol (CBD) in the management and treatment of neurological disorders
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REVIEW ARTICLE
Current application of cannabidiol (CBD) in the management and treatment of neurological disorders Brian Fiani 1 & Kasra John Sarhadi 2 & Marisol Soula 3 & Atif Zafar 4 & Syed A. Quadri 5 Received: 10 January 2020 / Accepted: 2 June 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Cannabidiol (CBD), which is nonintoxicating pharmacologically relevant constituents of Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative, anti-inflammatory, and neuroprotective effects. As the medicinal use of CBD is gaining popularity for treatment of various disorders, the recent flare-up of largely unproven and unregulated cannabisbased preparations on medical therapeutics may have its greatest impact in the field of neurology. Currently, as lot of clinical trials are underway, CBD demonstrates remarkable potential to become a supplemental therapy in various neurological conditions. It has shown promise in the treatment of neurological disorders such as anxiety, chronic pain, trigeminal neuralgia, epilepsy, and essential tremors as well as psychiatric disorders. While recent FDA-approved prescription drugs have demonstrated safety, efficacy, and consistency enough for regulatory approval in spasticity in multiple sclerosis (MS) and in Dravet and Lennox-Gastaut Syndromes (LGS), many therapeutic challenges still remain. In the current review, the authors have shed light on the application of CBD in the management and treatment of various neurological disorders. Keywords Cannabidiol . Efficacy . Ethicality . Neurologic disorders
Introduction Cannabis (marijuana) is a psychoactive drug used for recreational purposes and is known to have adverse health effects [1–3]. However, since past several years, pharmacologically relevant constituents of the Cannabis, apart from THC, have gained attention of research and legislation. The most prominent of those is cannabidiol (CBD), which is nonintoxicating but demonstrates several beneficial pharmacological effects. It has been found to have physiological effects such as antioxidative, anti-inflammatory, and neuroprotection [4–7].
It is the current opinion of many that neurology is facing a therapeutic dead end. The existing single target receptor pharmacotherapy has not proven generally useful in the face of complex neurological diseases. As the medicinal use of CBD is expanding worldwide, it is gaining popularity for treatment of various neurologic disorders such as anxiety, chronic pain, trigeminal neuralgia, epilepsy, and essential tremors as well as psychiatric disorders. In the current review, the authors have shed light on the application of CBD in the management and treatment of various neurological disorders.
Historical perspective on CBD * Syed A. Quadri [email protected] 1
Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, CA, USA
2
Miller School of Medicine, University of Miami, Miami, FL, USA
3
New York University School of Medicine, New York, NY, USA
4
Department of Neurology,
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