Cutaneous Drug Eruptions Diagnosis, Histopathology and Therapy
The use of medications globally is increasing, and as the baby boomer cohort ages, more people will survive with chronic illnesses managed with an ever more complex cocktail of pharmaceutical treatments. This book covers all aspects of the most challengin
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Cutaneous Drug Eruptions Diagnosis, Histopathology and Therapy
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Cutaneous Drug Eruptions
John C. Hall • Brian J. Hall Editors
Cutaneous Drug Eruptions Diagnosis, Histopathology and Therapy
Editors John C. Hall Kansas City Kansas USA
Brian J. Hall Miraca Life Sciences Irving Texas USA
ISBN 978-1-4471-6728-0 ISBN 978-1-4471-6729-7 DOI 10.1007/978-1-4471-6729-7
(eBook)
Library of Congress Control Number: 2015949115 Springer London Heidelberg New York Dordrecht © Springer-Verlag London 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag London Ltd. is part of Springer Science+Business Media (www.springer.com)
For the wonderful authors who made this book a reality and the patients to whose care they are so selflessly dedicated. Thank you also to the patients who graciously allowed their photographs to be used so this book could come to fruition.
Introduction
Use of medications in the population as a whole is increasing, and as the baby boomer cohort ages, more people will survive with chronic illnesses, and with new medical advances, there is an ever-increasing transplant population. One of the most difficult aspects of polypharmacy is allergic and toxic reactions to drugs. The skin is often the only or the earliest harbinger of multiorgan system damage in these patients. The skin is also the most easily observed and biopsied. Therefore, a textbook covering all aspects of this challenging dilemma seems apropos. That is what this treatise attempts to do. And in so doing, we hope to create an accessible resource for early detection and resolution of cutaneous drug reactions. Kansas City, MO, USA Irving, TX, USA
John C. Hall, MD Brian J. Hall, MD
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Contents
Part I
The Skin and Drug Interactions
1
Immunology of Cutaneous Drug Eruptions . . . . . . . . . . . . . . . . 3 Jon A. Dyer
2
Principles of Diagnosis of Cutaneous Drug Eruptions . . . . . . . 13 John C. Hall
3
Histopathology of Drug Reactions. . . . .
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