Neuroblastoma Diagnosis, Therapy, and Prognosis
Introduction of new technologies and their applications to neuroblastoma diagnosis, treatment, and therapy assessment are explained. Role of molecular ghenetics in diagnosis and therapy for neuroblastoma patients is detailed. Molecular detection of minima
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Pediatric Cancer, Volume 1 Diagnosis, Therapy, and Prognosis
For other titles published in this series, go to www.springer.com/series/10167
Pediatric Cancer Volume 1
Diagnosis, Therapy, and Prognosis
Neuroblastoma
Edited by
M.A. Hayat Distinguished Professor Department of Biological Sciences, Kean University, Union, NJ, USA
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Editor M.A. Hayat Department of Biological Sciences Kean University Union, NJ, USA [email protected]
ISSN 2211-7997 e-ISSN 2211-8004 ISBN 978-94-007-2417-4 e-ISBN 978-94-007-2418-1 DOI 10.1007/978-94-007-2418-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011939493 © Springer Science+Business Media B.V. 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Although touched by technology, surgical pathology always has been, and remains, an art. Surgical pathologists, like all artists, depict in their artwork (surgical pathology reports) their interactions with nature: emotions, observations, and knowledge are all integrated. The resulting artwork is a poor record of complex phenomena. Richard J. Reed MD
One Point of View
All small tumors do not keep growing, especially small breast tumors, testicular tumors, and prostate tumors. Some small tumors may even disappear without a treatment. Indeed, because prostate tumor grows slowly, it is not unusual that a patient may die, at an advanced age, of some other causes, but prostate tumor is discovered in an autopsy study. In some cases of prostate tumors, the patient should be offered the option of active surveillance followed by PSA test or biopsies. Similarly, every small kidney tumor may not change or may even regress. Another example of cancer or precancer reversal is cervical cancer. Precancerous cervical cells found with Pap test, may revert to normal cells. Tumor shrinkage, regression, reversal, or stabilization is not impossible. The pertinent question is: Is it always necessary to practice tumor surgery, chemotherapy, or radiotherapy? Although the conventional belief is that cancer represents an “arrow that advances unidirectionally,” it is becoming clear that for cancer to progress, they require cooperative microenvironment (nitch), including immune system and hormone levels. However, it is emphasized that advanced (malignant) cancers do not show regression, and require therapy. In the light of the inadequacy of standard treatments of malignancy, clinical applications of the stem cell technology need to be expedited. Eric Hayat
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Preface
Volume 1 discussing diagnosis, therapy, and prognosis of children with neuroblastoma is part of
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