Cytokine Storm Syndrome
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to
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Cytokine Storm Syndrome
Cytokine Storm Syndrome
Randy Q. Cron • Edward M. Behrens Editors
Cytokine Storm Syndrome
Editors Randy Q. Cron UAB School of Medicine University of Alabama at Birmingham Birmingham, AL, USA
Edward M. Behrens Perelman School of Medicine University of Pennsylvania Philadelphia, PA, USA
ISBN 978-3-030-22093-8 ISBN 978-3-030-22094-5 (eBook) https://doi.org/10.1007/978-3-030-22094-5 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
This textbook was necessitated by the broadening recognition of cytokine storm syndromes (CSS) and their import and impact on health worldwide. We dedicate this to the clinicians and scientists who explore CSS and to the patients and their families who allow us to learn how best to diagnose and treat CSS. We also would like to dedicate this work to our families who supported us during the process of preparing this textbook.
Foreword
The coeditors of the textbook Doctors Cron and Behrens have bravely embarked on the ambitious course of bringing together a group of international experts to dissect the current knowledge of cytokine storm syndrome (CSS) underlying both the primary (p) and secondary (s) haemophagocytic lymphohistiocytosis (HLH). The resulting state-of-the-art chapters cover the historic background, clinical and laboratory features, criteria for diagnosis, and current classification (Part I), pathophysiology (genetics, immunology, and murine models—Parts II, III, VII, respectively), different potential triggers (infections, rheumatic, various others—Parts IV, V, VI, respectively), and current treatment options (Part VIII). Raising awareness of the CSS within the wide physician comm
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