Data Integration in the Life Sciences 7th International Conferen

The development and increasingly widespread deployment of high-throughput experimental methods in the life sciences is giving rise to numerous large, c- plex and valuable data resources. This foundation of experimental data und- pins the systematic study

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Patrick Lambrix Graham Kemp (Eds.)

Data Integration in the Life Sciences 7th International Conference, DILS 2010 Gothenburg, Sweden, August 25-27, 2010 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Patrick Lambrix Linköpings universitet Department of Computer and Information Science, 581 83 Linköping, Sweden E-mail: [email protected] Graham Kemp Chalmers University of Technology and University of Gothenburg Computer Science and Engineering, 412 96, Gothenburg, Sweden E-mail: [email protected]

Library of Congress Control Number: 2010932135

CR Subject Classification (1998): H.3, J.3, I.2, H.4, C.2, H.5 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-642-15119-1 Springer Berlin Heidelberg New York 978-3-642-15119-4 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. springer.com © Springer-Verlag Berlin Heidelberg 2010 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper 06/3180

Preface

The development and increasingly widespread deployment of high-throughput experimental methods in the life sciences is giving rise to numerous large, complex and valuable data resources. This foundation of experimental data underpins the systematic study of organisms and diseases, which increasingly depends on the development of models of biological systems. The development of these models often requires integration of diverse experimental data resources; once constructed, the models themselves become data and present new integration challenges for tasks such as interpretation, validation and comparison. The Data Integration in the Life Sciences (DILS) Conference series brings together data and knowledge management researchers from the computer science research community with bioinformaticians and computational biologists, to improve the understanding of how emerging data integration techniques can address requirements identified in the life sciences. DILS 2010 was the seventh event in the series and was held in Gothenburg, Sw