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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Jinyan Li Qiang Yang Ah-Hwee Tan (Eds.)

Data Mining for Biomedical Applications PAKDD 2006 Workshop, BioDM 2006 Singapore, April 9, 2006 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Jinyan Li Institute for Infocomm Research 21 Heng Mui Keng Terrace, Singapore 119613 E-mail: [email protected] Qiang Yang Hong Kong University of Science and Technology, Department of Computer Science Clearwater Bay, Kowloon, Hong Kong, China E-mail: [email protected] Ah-Hwee Tan Nanyang Technological University, School of Computer Engineering Nanyang Avenue, Singapore 639789 E-mail: [email protected]

Library of Congress Control Number: 2006922190

CR Subject Classification (1998): H.2.8, J.3, I.2, H.3, I.5, F.1 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-33104-2 Springer Berlin Heidelberg New York 978-3-540-33104-9 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 11691730 06/3142 543210

Preface

This edited volume contains the papers selected for presentation at the First Workshop on Data Mining for Biomedical Applications (BioDM 2006) held in Singapore on April 9, 2006. The workshop was held in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006), a leading international conference in the areas of data mining and knowledge discovery. The aim of this workshop was to provide a forum for discussing research topics related to biomedical applications where data mining techniques were found to be necessary and/or useful. BioDM 2006 received a total of 35 full-length paper submissions from seven countries. Each submitted paper was rigorously reviewed by three Program Committee members. Although many papers were worthy of publication, only 14 regular papers can be accepted in the workshop for presentatio