Data Mining Study on Prescription Patterns of Different Dosage Forms of Chinese Herbal Medicines for Treating and Improv
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hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
Data Mining Study on Prescription Patterns of Different Dosage Forms of Chinese Herbal Medicines for Treating and Improving Immune-Inflammatory Indices in Patients with Rheumatoid Arthritis HUANG Dan1, LIU Jian1, XIN Ling1, XIE Jin-gui2, ZHU Qiang3, CHEN Pei-sheng3, SHEN Zhi-bin4, MENG Qing-he5, and WANG Hai-yan5 Objective:: To explore the prescription patterns of different dosage forms of Chinese herbal ABSTRACT Objective medicines (CHMs) for the treatment of rheumatoid arthritis (RA) and their effects on immune-inflammatory Methods:: Clinical data were collected from patients with RA in 4 hospitals (3 Class A comprehensive indices. Methods hospitals and 1 Class B comprehensive hospital) in Anhui Province, China, from August 2012 to June 2018 via the electronic medical record gathering system. Following extraction of prescription information, each prescribed herb was quantified and standardized according to the knowledge base to establish a database of RA treatment formulae. The medical records were divided into the granules group and decoction pieces group. Core herbs and their combination patterns were obtained from the two groups of cases using Liquorice software. Changes in immune-inflammatory and hepatic and renal function indices were compared between the two groups using SPSS 23.0 software. The Aprior module of SPSS Clementine 11.1 software was applied to analyse the correlation between CHMs and improvement in indices. Finally, the ORACLE 10 g tool was used to evaluate the random Results:: (1) We retrospectively analysed walk model of the immune-inflammatory indices between the two groups. Results 35,898 prescriptions for 6,829 patients with RA who received CHM treatment. There were 3,816 patients in the granules group and 3,013 in the decoction pieces group. (2) The core herbs were Pi (Spleen)-strengthening and dampness-resolving drugs, blood-activating and stasis-resolving drugs, wind/dampness-dispelling drugs and heatclearing and detoxifying drugs. (3) Both dosage forms could improve immune-inflammatory indices in RA ©The Chinese Journal of Integrated Traditional and Western patients, with similar efficacy and no influence on Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020 hepatic or renal function. (4) Herba Siegesbeckiae Supported by the National Key Research and Development and Oldenlandia had a stronger association with Program of the Ministry of Science and Technology (No. immune-inflammatory indices in the two groups. (5) 2018YFC1705204), the Major Science and Technology Project of Anhui Province (No. 17030801009), the Key Research and The immune-inflammatory indices showed obvious Development Projects of Foreign Scientific and Technological improvement after treatment with granules and Cooperation planned in Anhui Province (No. 201904b11020011), the Anhui Provincial Lab
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