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Practical Manual of Fetal Pathology

Jelena Martinovic Editor

Practical Manual of Fetal Pathology Foreword by John M. Opitz

Editor Jelena Martinovic Department of Fetal Pathology Antoine Béclère Hospital, AP-HP Paris Saclay University Paris France

ISBN 978-3-030-42491-6    ISBN 978-3-030-42492-3 (eBook) https://doi.org/10.1007/978-3-030-42492-3 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

On a Prefatory Note Fetoplacental pathology is the last frontier of human biology and medicine given the appalling prenatal death rate of our species (>50%), much of which remains unexplored. By “fetoplacental” I understand the fetus from term to 57 days of gestation, the embryo from 56 days to fertilization, and the placenta as all trophic tissue at all stages, intact or in pieces, to be sorted from decidua and clots in the lab. And I do so in the hope that all of you are or will be working in services that cover all pregnancy stages without sequestering those up to 12 weeks of gestational age as “products of conception” into Surgical Pathology where they may receive only stepmotherly attention. And, finally I do so with the expectation and confidence that your place of work is not just a perfunctory service morgue but also an exciting classroom open to any and all advances in developmental biology, pathology, and genetics and a laboratory initiating research in all of these areas toward a better and deeper understanding of human ontogeny. Innumerable causes of prenatal death in humans are yet to be discovered—mutations, TADs, aneuploidies, infections, maternal-placental and epigenetic factors, teratogenic disruptors. Thus, it is with great p