Decreased LAG3 expression on T effector cells and regulatory T cells in SAA
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ORIGINAL ARTICLE
Decreased LAG3 expression on T effector cells and regulatory T cells in SAA Yingying Sun1 · Chunyan Liu1 · Ting Jiao1 · Ning Xie1 · Huaquan Wang1 · Weiwei Qi1 · Zonghong Shao1 Received: 28 January 2020 / Revised: 26 July 2020 / Accepted: 6 August 2020 © Japanese Society of Hematology 2020
Abstract Objective To investigate the expression of lymphocyte activation gene 3(LAG3) on CD8+T effector cells (Teffs), CD4+ Teffs and regulatory T cells (Tregs) in patients with severe aplastic anemia (SAA). Methods We detected the expression of LAG3 on C D8+ Teffs, CD4+ Teffs and Tregs in SAA patients and healthy controls (HC) by flow cytometry, and analyzed its correlation with the immune status and severity of the disease. ELISA was used to detect soluble LAG3(sLAG3). Results The expression of LAG3 on C D8+ Teffs, C D4+ Teffs and Tregs in untreated SAA patients were significantly lower than those in HC group (P
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