Decreased platelet-to-lymphocyte ratio as predictor of thrombogenesis in nonvalvular atrial fibrillation
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Atrial fibrillation (AF), the most common arrhythmia worldwide, is linked to a high risk of stroke or thromboembolism [1]. Inflammation and atrial fibrosis play a key role throughout the atrial electrical and structural remodeling processes and form the substrate not only for AF but also for stroke [2, 3]. Left atrial appendage flow velocity (LAA-FV) is a direct marker of blood stasis [4]. Left atrial (LA) strain measured by transthoracic echocardiography (TTE) is a noninvasive method by which the extent of LA remodeling can be determined [5]. The platelet-tolymphocyte ratio (PLR) is a repeatable and easily obtainable novel biomarker of systemic inflammatory burden [6]. Thus, the present study was conducted to explore the role of PLR in reflecting decreased LAA-FV and impaired LA strain.
Methods Study population This retrospective study included patients with nonvalvular AF (NVAF), and the following exclusion criteria were applied: autoimmune disease, clinically significant valvular heart disease, acute coronary syndrome, renal failure, acute heart failure, severe hypertrophic cardiomyopathy (>20 mm), previous ablation history, acute stroke, cancer, This manuscript is the authors’ original work and has not been published nor has it been submitted simultaneously elsewhere. All authors have seen the manuscript and approved it for publication.
K. Zuo · X. Yang Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Decreased platelet-tolymphocyte ratio as predictor of thrombogenesis in nonvalvular atrial fibrillation ongoing infection, thyroid dysfunction, hematological disease, malignancy, or other systemic inflammatory conditions. Patients with high-sensitive C-reactive protein values of >3 mg/l and a white blood cell count of >12,000 cells/μl or 88,16 (0,38 vs. 0,77; p = 0,02). Schlussfolgerung. Ein niedrigerer PLR lag bei Patienten mit nichtvalvulärem Vorhofflimmern und einer verminderten LAA-FV vor. Sein Zusammenhang mit der linksatrialen Deformation könnte einen Hinweis auf die Bedeutung von Entzündungsprozessen bei der Progression des atrialen Remodelings und bei erhöhtem Thromboserisiko darstellen. Schlüsselwörter Atriales Remodeling · Schlaganfall · Entzündung · Thrombozyten-LymphozytenQuotient · Deformation
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References
Fig. 1 9 Receiver operating characteristic curve analysis of platelet-tolymphocyte ratio for predicting decreased left atrial appendage flow velocity
LA strain—the most easily visualized and convenient marker of blood stasis and LA remodeling—has not been extensively evaluated to date. In our study, we found that a lower PLR was associated with decreased LAA-FV and impaired LA strain, providing some evidence of its close link to inflammation, thromboembolism, and LA remodeling.
an easily obtainable biomarker, providing a simple method for identifying patients with high prothrombotic risk in clinical practice. Moreover, these findings confirmed the view, from another perspective, of the comprehensive role of
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