Deep Brain Stimulation in the Nucleus Accumbens for Binge Eating Disorder: a Study in Rats
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Deep Brain Stimulation in the Nucleus Accumbens for Binge Eating Disorder: a Study in Rats D. L. Marinus Oterdoom 1 & Renske Lok 2 & André P. van Beek 3 & Wilfred F.A. den Dunnen 4 & Marloes Emous 5 & J. Marc C. van Dijk 1 & Gertjan van Dijk 2
# The Author(s) 2020
Abstract Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twentyone male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED. Keywords Deep brain stimulation . Nucleus accumbens . Binge eating disorder . Animal study
Introduction Binge eating disorder (BED) affects approximately 30% of obese patients. It is characterized by recurrent episodes of binge eating without compensatory behavior, e.g., vomiting or laxative abuse [1]. BED is associated with poor outcome
after “gastrointestinal” bariatric surgery [2] and is therefore regarded as an exclusion criterion for these surgeries. BED is hypothesized to result from maladaptive changes in the cerebral reward system. Neuro-anatomically, reward experience is mediated by a network of cortical regions and basal ganglia, with the nucleus accumbens (NAC) as a key structure
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11695-020-04697-9) contains supplementary material, which is available to authorized users. * Gertjan van Dijk [email protected] D. L. Marinus Oterdoom [email protected]
1
Department of Neurosurgery, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands
2
Department of Behavioral Neuroscience, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG Groningen, the Netherlands
3
Department of Endocrinology, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands
4
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
5
Department of Bariatric and Metabolic Surgery, Medical Center Leeuwarden, Leeuwarden, the Netherlands
Renske Lok [email protected] André P. van Beek [email protected] Wilfred F.A. den Dunnen [email protected] Marloes Emous [email protected] J. Marc C. van Dijk [email protected]
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in this circuitry. The NAC is implicated in med
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