Modeling nucleus accumbens
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Modeling nucleus accumbens A Computational Model from Single Cell to Circuit Level Rahmi Elibol1,2
¨ 1 · Neslihan Serap S¸engor
Received: 22 May 2020 / Revised: 9 October 2020 / Accepted: 14 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Nucleus accumbens is part of the neural structures required for reward based learning and cognitive processing of motivation. Understanding its cellular dynamics and its role in basal ganglia circuits is important not only in diagnosing behavioral disorders and psychiatric problems as addiction and depression but also for developing therapeutic treatments for them. Building a computational model would expand our comprehension of nucleus accumbens. In this work, we are focusing on establishing a model of nucleus accumbens which has not been considered as much as dorsal striatum in computational neuroscience. We will begin by modeling the behavior of single cells and then build a holistic model of nucleus accumbens considering the effect of synaptic currents. We will verify the validity of the model by showing the consistency of simulation results with the empirical data. Furthermore, the simulation results reveal the joint effect of cortical stimulation and dopaminergic modulation on the activity of medium spiny neurons. This effect differentiates with the type of dopamine receptors. Keywords Nucleus accumbens · Medium spiny neuron · Local field potential · Computational model
1 Introduction Basal Ganglia (BG) are a group of nuclei located subcortically in the brain which take information mainly from cerebral cortex and convey to frontal cortex via thalamus (Yelnik 2002). Functionally, BG are found at the junction of neural circuits responsible for emotional, cognitive and motor functions (Alexander and Crutcher 1990; Haber et al. 2000). Thus, they take role not only in motor actions but also in cognitive processes and their malfunctioning induce various behavioral and neurological disorders (DeLong and Wichmann 2007; Halje et al. 2019). Striatum, being the main input nucleus of BG and the target of dopaminergic modulation has an important part in the BG functions. Nucleus Accumbens (NAcc) is part of striatum Action Editor: David Terman Rahmi Elibol
[email protected] 1
Electronics and Communication Engineering, Istanbul Technical University, Istanbul, Turkey
2
Engineering Faculty, Erzincan University, Erzincan, Turkey
and though there are a lot of data on the structure and functions of NAcc (Neto et al. 2008; Salgado and Kaplitt 2015; Prensa et al. 2003; Mavridis et al. 2011; Lucas-Neto et al. 2013; Pijnenburg and Van Rossum 1973; Salamone 1994), only recently its place is pinpointed (Neto et al. 2008) and evidence about its role in neural disorders related to mesolimbic pathway is perceived (Salgado and Kaplitt 2015; Yohn et al. 2019). There are numerous computational models of BG mostly addressing their role in action selection (Taylor and Taylor 2000; Gurney et al. 2001a; 2001b; Sengor and Karabacak 2015; Guthrie et al.
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