Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Societ
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ORIGINAL ARTICLE
Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology‑Glomerular Diseases (TSN‑GOLD) Working Group Zeki Aydin1 · Kultigin Turkmen2 · Fatih Dede3 · Emre Yasar4 · Savas Ozturk5 · Mehmet Aydin6 · Erhan Tatar7 · Garip Sahin8 · Gulizar Manga9 · Ozgur Oto10 · Abdullah Sumnu11 · Eray Eroglu12 · Tamer Dincer13 · Belda Dursun14 · Necmi Eren15 · Mustafa Sevinc16 · Fatma Betul Guzel17 · Serkan Yalin18 · Sim Kutlay19 · Suheyla Apaydin20 · Haci Bayram Berktas21 · Sinan Kazan22 · Hamad Dheir23 · Feyza Bora24 · Taner Basturk16 · Idris Sahin21 Received: 2 April 2020 / Accepted: 29 September 2020 © Japanese Society of Nephrology 2020
Abstract Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m2 and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed. Keywords Rapidly progressive glomerulonephritis · Anti-glomerular basement membrane antibody · Immune complex glomerulonephritis · Anti-neutrophil cytoplasmic antibody
Introduction Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome defined by the rapid loss of renal function, accompanied by features of the nephritic syndrome with proteinuria, glomerular haematuria and often oliguria. Although relatively uncommon, early recognition and prompt diagnosis * Zeki Aydin [email protected] Extended author information available on the last page of the article
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