Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG)
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ORIGINAL ARTICLE
Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG) ¨ zgu¨r Tanrıverdi2 • Go¨rkem Tu¨rkkan1 • Ali Alkan2 • Semra Paydas¸ 3 • O Yusuf Karakas¸ 4 • Nuri Karadurmus¸ 5 • Abdullah Sakin6 • Su¨leyman Temiz7 Erkan Arpacı8 • Mustafa Akın9 • Serkan Meneks¸ e10 • Cenk Ahmet S¸ en11 • I˙brahim Barıs¸ ta4
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Received: 21 October 2019 / Accepted: 28 January 2020 Ó Indian Society of Hematology and Blood Transfusion 2020
Abstract Marginal zone lymphomas (MZLs) are rare and indolent subtypes of non-Hodgkin lymphomas, and their clinical behaviours are heterogeneous. The aim of this study was to evaluate the clinical and prognostic characteristics of MZL. In this multicentre retrospective study, we analyzed demographical, clinical and prognostic features of 64 MZL patients. The median age was 54.0 and 78.1% of the patients had extra-nodal disease at presentation. Most of the patients were treated with chemotherapy. The 5 years and 10 years overall survival (OS) rates were 74.5% and 62.1%, respectively. The analysis of factors associated with OS showed that ECOG performance score was an important prognostic factor, with 133.0 months (95% CI 49.3–216.5) versus 18.0 months (95% CI 12.1–23.7) for ECOG 0–1 and 2–3, respectively (p = 0.011). Prognosis of MZL is favorable and ECOG performance score was found associated with OS. Further detailed studies with large patient numbers are needed to
& Go¨rkem Tu¨rkkan [email protected] 1
Department of Radiation Oncology, Mug˘la Sıtkı Koc¸man University Medical Faculty, Mug˘la, Turkey
2
Department of Medical Oncology, Mug˘la Sıtkı Koc¸man University Medical Faculty, Mug˘la, Turkey
3
Department of Medical Oncology, C¸ukurova University Medical Faculty, Adana, Turkey
4
Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey
5
Department of Medical Oncology, Gu¨lhane Training and Research Hospital, Ankara, Turkey
6
Department of Medical Oncology, Okmeydanı Training and Research Hospital, Istanbul, Turkey
clarify the clinical features and treatment management of MZLs. Keywords Marginal zone lymphoma MALT lymphoma Chemotherapy Radiotherapy Prognosis
Introduction Marginal zone lymphoma (MZL) is a rare subtype of nonHodgkin lymphomas (NHLs), accounting for 3–9% of all NHL cases [1]. It arises from post-germinal center marginal zone B cells. According to World Health Organization classification of lymphoid neoplasms, there are subtypes of MZL; extranodal MZL of mucosa associated lymphoid tissue (MALT lymphoma), nodal MZL and splenic MZL. All subtypes of MZL share morphologic and immunophenotypical similarities; however molecular and clinical characteristics differ for each entity [2]. Primary 7
Department of Medical Oncology, Kocaeli Acıbadem Hospital, Kocaeli, Turkey
8
Department of Medical Oncology, Bu¨lent Ecevit University Medical Faculty, Zonguldak, Turkey
9
Department of Radiation Oncology, Balıkesir State Hospital, Balıkesir, Turkey
10
Departme
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