Dendrimers and Viruses
Dendrimers, as hyperbranched synthetic well-defined molecules, have been suggested as potential antivirals from several reasons, such as their small sizes (nanometers) and their ease of preparation and functionalization. Importantly they can be potent inh
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ˇ Jaroslav Sebest´ ık
Milan Reiniˇs
Jan Jeˇzek
Biomedical Applications of Peptide-, Glycoand Glycopeptide Dendrimers, and Analogous Dendrimeric Structures
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ˇ Jaroslav Sebest´ ık Department of Molecular Spectroscopy Institute of Organic Chemistry and Biochemistry, AS CR, vvi Prague Czech Republic
Jan Jeˇzek Laboratory of Glycoconjugates Institute of Organic Chemistry and Biochemistry, AS CR, vvi Prague Czech Republic
Milan Reiniˇs Institute of Molecular Genetics AS CR, vvi Prague Czech Republic
ISBN 978-3-7091-1205-2 ISBN 978-3-7091-1206-9 (eBook) DOI 10.1007/978-3-7091-1206-9 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2012954529 © Springer-Verlag Wien 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The purpose of this book is to show the progress in the field of synthesis and biomedical applications of peptide-, glyco-, glycopeptide dendrimers and analogous dendrimeric structures. This booklet is intended to graduate students, advanced undergraduates, and scientists working in the area of organic chemistry, biochemistry, nanoscience, biology, medicinal chemistry, and biomedical applications. Dendrimers and dendritic macromolecules were pioneered in the 1980s. They represent a dynamica
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