Viruses and Nanotechnology
Nanobiotechnology involves the exploitation of biomaterials, devices or methodologies at the nanoscale. Virus particles are natural nanomaterials and have received particular attention as novel building blocks for materials design and fabrication. In this
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Series Editors Richard W. Compans Emory University School of Medicine, Department of Microbiology and Immunology, 3001 Rollins Research Center, Atlanta, GA 30322, USA Max D. Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA Tasuku Honjo Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan Hilary Koprowski Thomas Jefferson University, Department of Cancer Biology, Biotechnology Foundation Laboratories, 1020 Locust Street, Suite M85 JAH, Philadelphia, PA 19107-6799, USA Fritz Melchers Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstr. 50–70, 4056 Basel Switzerland Michael B.A. Oldstone Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines, La Jolla, CA 92037, USA Sjur Olsnes Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo, Norway Peter K. Vogt The Scripps Research Institute, Dept. of Molecular & Exp. Medicine, Division of Oncovirology, 10550 N. Torrey Pines. BCC-239, La Jolla, CA 92037, USA
Marianne Manchester • Nicole F. Steinmetz Editors
Viruses and Nanotechnology
Editors Marianne Manchester Department of Cell Biology Center for Integrative Molecular Biosciences Scripps Research Institute CB262 10550 N. Torrey Pines Road La Jolla, CA 92037 USA [email protected]
Nicole F. Steinmetz Department of Cell Biology Center for Integrative Molecular Biosciences Scripps Research Institute CB262 10550 N. Torrey Pines Road La Jolla, CA 92037 USA [email protected]
Cover legend: Atomic model of 31 nm cowpea mosaic virus (CPMV) nanoparticles derivatized with gold on surface cysteines. A mutant of CPMV bearing 60 surface cysteine residues was conjugated to nanogold. Golden spheres indicating electron density of the attached gold particles are superimposed on the atomic structure of the virus capsid proteins, indicated by red, green, and purple ribbon structures. Model courtesy of Dr. John E. Johnson, Scripps Research Institute, La Jolla, CA, USA.
ISBN 978-3-540-69376-5 e-ISBN 978-3-540-69379-6 DOI 10.1007/978-3-540-69379-6 Current Topics in Microbiology and Immunology ISSN 0070-217x Library of Congress Catalog Number: 2008931406 © 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this pub
