Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome
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DIAGNOSTIC NEURORADIOLOGY
Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome Shun Sakamoto 1 & Takashi Kimura 1
&
Koji Kajiyama 1 & Kumiko Ando 2 & Masanaka Takeda 1 & Hiroo Yoshikawa 1
Received: 13 May 2020 / Accepted: 16 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The word “fixel” refers to the specific fiber population within each voxel, and fixel-based analysis (FBA) is a recently developed technique that facilitates fiber tract-specific statistical analysis. The aim of the paper is to apply FBA to detect impaired fibers for corticobasal syndrome (CBS) especially in regions that contain multiple crossed fibers. Methods FBA was performed in cohorts of participants clinically diagnosed with CBS (n = 10) and Parkinson’s disease (n = 15) or in healthy controls (n = 9). The parameters of the diffusion weighted image were echo time, 83 ms; time, 8123.6 ms; flip angle, 90°; section thickness, 2 mm; b = 1000 s/mm2; and 32 axes. Diffusion tensor analysis was conducted using tract-based spatial statistics (TBSS), and white matter volume was estimated via voxel-based morphometry. Results A comparison of PD or HC to CBS revealed a significant difference in the dentatorubrothalamic tract of the brainstem in FBA in addition to the affected regions in voxel-based morphometry and TBSS (family-wise error-corrected p < 0.05). Reduction of the white matter fibers crossing the brainstem could not be detected via microstructural changes identified using TBSS, but it was detected using FBA. Conclusion FBA has some advantages in determining the distribution of corticobasal syndrome lesions. Keywords Corticobasal syndrome . Dentatorubrothalamic tract . Fixel . MRI . White matter
Introduction In recent years, there has been an increase in studies investigating whether neuroimaging analysis of white matter (WM) changes is useful for differentiating atypical parkinsonism, such as corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), from Parkinson’s disease (PD) [1–6]. To this end, diffusion tensor imaging (DTI) has been extensively used. Still, there are limitations associated with the
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00234-020-02559-w) contains supplementary material, which is available to authorized users. * Takashi Kimura [email protected] 1
Department of Neurology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
2
Department of Radiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
analysis of crossing fibers, which have been estimated to be present in up to 90% of WM voxels [7]. The word “fixel” refers to the specific fiber population within each voxel, and a recently developed technique based on fixel-based analysis (FBA) has been shown to facilitate statistical analysis of tract-specific fiber populations, where fiber orientation distribution is estimated via constrained spherical deconv
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