Derivation of attenuation map for attenuation correction of PET data in the presence of nanoparticulate contrast agents
- PDF / 1,116,591 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 25 Downloads / 164 Views
ORIGINAL ARTICLE
Derivation of attenuation map for attenuation correction of PET data in the presence of nanoparticulate contrast agents using spectral CT imaging Hossein Ghadiri • Mohammad Bagher Shiran Hamid Soltanian-Zadeh • Arman Rahmim • Habib Zaidi • Mohammad Reza Ay
•
Received: 2 December 2013 / Accepted: 20 March 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Objective Uptake value in quantitative PET imaging is biased due to the presence of CT contrast agents when using CT-based attenuation correction. Our aim was to examine spectral CT imaging to suppress inaccuracy of 511 keV attenuation map in the presence of multiple nanoparticulate contrast agents. Methods Using a simulation study we examined an image-based K-edge ratio method, in which two images acquired from energy windows located above and below the K-edge energy are divided by one another, to identify the exact location of all contrast agents. Multiple computerized phantom studies were conducted using a variety of NP contrast agents with different concentrations. The performance of the proposed methodology was compared to conventional single-kVp and dual-kVp methods using wide range of contrast agents with varying concentrations.
Results The results demonstrate that both single-kVp and dual-kVp energy mapping approaches produce inaccurate attenuation maps at 511 keV in the presence of multiple simultaneous contrast agents. In contrast, the proposed method is capable of handling multiple simultaneous contrast agents, thus allowing suppression of 511 keV attenuation map inaccuracy. Conclusion Attenuation map produced by spectral CT clearly outperforms conventional single-kVp and dual-kVp approaches in the generation of accurate attenuation maps in the presence of multiple contrast agents.
H. Ghadiri M. R. Ay (&) Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]; [email protected]
A. Rahmim Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
H. Ghadiri M. R. Ay Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran M. B. Shiran Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran H. Soltanian-Zadeh CIPCE, Department of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
Keywords PET/CT Nanoparticulate contrast agents K-edge imaging Multi-energy spectral CT
H. Zaidi Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland H. Zaidi Geneva Neuroscience Center, Geneva University, Geneva, Switzerland H. Zaidi Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
H. Soltanian-Zadeh Department of Radiology, Henry Ford Health System, Detroit, MI, USA
123
Ann Nucl Med
Introduction The quantitative accuracy of PET images when using CTbased attenuation correction (CTAC) might be compromised in
Data Loading...
