Design, characterization and in vitro evaluation of thin films enriched by tannic acid complexed by Fe(III) ions
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ORIGINAL RESEARCH
Design, characterization and in vitro evaluation of thin films enriched by tannic acid complexed by Fe(III) ions B. Kaczmarek1,4 · O. Mazur1 · O. Miłek2 · M. Michalska‑Sionkowska3 · A. Das4 · A. Jaiswal4 · J. Vishnu4 · K. Tiwari4 · A. Sionkowska1 · A. M. Osyczka2 · G. Manivasagam4 Received: 10 August 2020 / Accepted: 13 November 2020 © The Author(s) 2020
Abstract Materials based on carbohydrate polymers may be used for biomedical application. However, materials based on natural polymers have weak physicochemical properties. Thereby, there is a challenge to improve their properties without initiation of toxicity. The alternative method compared to toxic chemical agents’ addition is the use of metal complexation method. In this study, chitosan/tannic acid mixtures modified by Fe(III) complexation are proposed and tested for potential applications as wound dressings. Thereby, surface properties, blood compatibility as well as platelet adhesion was tested. In addition, the periodontal ligament stromal cells compatibility studies were carried out. The results showed that the iron(III) addition to chitosan/tannic acid mixture improves properties due to a decrease in the surface free energy and exhibited a reduction in the hemolysis rate (below 5%). Moreover, cells cultured on the surface of films with Fe(III) showed higher metabolic activity. The current findings allow for the medical application of the proposed materials as wound dressings. Keywords Complexation · Iron (III) complexes · Polyphenol
Introduction Materials for skin dressing and wound healing should be biocompatible, bioactive, provide defensive action against bacteria and stimulate angiogenesis to support the active healing process (Kaczmarek et al. 2019a). Conventional scaffold materials are made from materials used for such applications which possess the undesirable properties such as absorption of fluids from the wound, clinging to the * B. Kaczmarek [email protected] 1
Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87‑100 Torun, Poland
2
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Kraków, Gronostajowa 7, Krakow, Poland
3
Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Veterinary Science, Nicolaus Copernicus University in Toruń, Lwowska 1, Torun, Poland
4
Centre for Biomaterials Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore, Tamil Nadu, India
wound surface, and causing injury during the removal of dressing (Singh et al. 2013). Novel dressing materials are non-adherent to the wound and have the ability to create a moist environment near the wound by keeping the wound fluids in contact with the wound (Singh et al. 2013; Phaechamud et al. 2016; Kaczmarek et al. 2019b). Chitosan, a linear polymer of α-(1 → 4)-linked 2-amino2-deoxy-β-d-glucopyranose (Dutta et al. 2004) is the key
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