Design of selective cell migration biomaterials and their applications for tissue regeneration
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Design of selective cell migration biomaterials and their applications for tissue regeneration Yang Cui1,2, Ying Yang3,*, and Dong Qiu1,2,* 1
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, CAS Research/ Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China 2 University of Chinese Academy of Sciences, Beijing 100190, China 3 The People’s Hospital of Suzhou New District, Suzhou 215129, Jiangsu, China
Received: 29 July 2020
ABSTRACT
Accepted: 3 November 2020
Cell migration is a widespread form of live cell activity during complex dynamic process, which plays an important role in tissue regeneration and repairing. Tissue regenerative biomaterials provide the basic supporting for the growth of cells and tissues and maintain the shape and mechanical properties of the regenerated tissues. Cell recruitment and migration with the assistance of biomaterials is important for tissue regenerative process because cell directional migration to the wound site is a crucial prerequisite in tissue regeneration. In the case of injured tissue, migration and overgrowth of unexpected cells may cause severe diseases. Hence, cell-selective biomaterials have great significance in tissue regeneration and reconstruction. The design of cell-selective biomaterials for this purpose is based on the specific interactions between materials and cells by the physical, chemical, or biological cues, because they can directly affect the migration cells and further affect the process of tissue regeneration. The chemical and biological molecules (peptides, growth factors, adhesion molecules), physical properties (hardness, topography, hydrophilicity), physiological signals (cellular chemokines or cytokines) are all effective regulatory factors in the design of cell-selective biomaterials. This review combined the latest research, summarized systematically about the influential factors of cell migration, the design of biomaterials for selective cell adhesion and directional migration, and their applications in tissue regeneration. Furthermore, the challenge and perspectives of cell-selective migration biomaterials were also discussed.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Maude Jimenez.
Address correspondence to E-mail: [email protected]; [email protected]
https://doi.org/10.1007/s10853-020-05537-y
J Mater Sci
Introduction Cell movement plays a crucial role in a variety of physiological and pathological processes including embryonic development, immune response [1, 2], wound healing [3, 4], angiogenesis [5, 6], and cancer metastasis [7, 8]. For example, the fibroblasts migrate into the blood clots in the wound site under the guidance of inflammatory factors released from the wound and cover the defect area [9]. At the same time, epithelia proliferate and migrate to the defect surface to form epithelialization [10]. There are many pluripotent stem cells and directe
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