Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of antican
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Designed poly(ethylene glycol) conjugate-erbiumdoped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug Kiruthiga Kaliyamoorthi1, Archana Sumohan Pillai2, Aleyamma Alexander2, Sivaraj Ramasamy2, Anitha Arivarasu1, and Israel V. M. V. Enoch2,* 1
Department of Chemistry and Department of Chemical Engineering, Hindustan Institute of Technology and Science, Chennai, Tamil Nadu 603103, India 2 Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu 641114, India
Received: 26 June 2020
ABSTRACT
Accepted: 16 October 2020
Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO3 nanoparticles and their magnetic characteristics. In addition, we report a b-cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Maude Jimenez.
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05466-w
J Mater Sci
GRAPHICAL ABSTRACT
Introduction Chemotherapy remains as an essential treatment method for curing cancer. Nevertheless, it depends on cytotoxic chemotherapeutic drugs that limits the clinical application [1]. To overcome the severity and side effects of chemotherapy, drug delivery systems (DDS) are employed [2]. There are challenges faced by the DDSs because the differentiation between normal and cancerous cells has to be achieved. In addition, the DDSs suffer a premature drug release [3]. To overcome this, magnetic field-assisted drug delivery is preferred and various magnetic nanomaterials have been reported as DDSs [4–7]. To improve their precision, newer attempts are made, focusing on tailor-making of nanoparticles of suitable sizes and shapes, modifying their surface with appropriate ligands or polymers, utilizing an applied magnetic field to direct the NPs in the circulatory system, and attachment of targeting ligands like folic acid on the surface of the NPs [8]. The size of the nanocarrier should be in a desired range i.e., above 10 nm and below 200 nm, to make them possess a long circulation time [9, 10]. In addition, the surface should be biocompatibl
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