Designing Droplet Microfluidic Networks A Toolbox for Designers
This book describes automatic methods for the design of droplet microfluidic networks. The authors discuss simulation and design methods which support the design process of droplet microfluidics in general, as well as design methods for a dedicated drople
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signing Droplet Microfluidic Networks A Toolbox for Designers
Designing Droplet Microfluidic Networks
Andreas Grimmer • Robert Wille
Designing Droplet Microfluidic Networks A Toolbox for Designers
123
Andreas Grimmer Institute for Integrated Circuits Johannes Kepler University Linz Linz, Austria
Robert Wille Institute for Integrated Circuits Johannes Kepler University Linz Linz, Austria
ISBN 978-3-030-20712-0 ISBN 978-3-030-20713-7 (eBook) https://doi.org/10.1007/978-3-030-20713-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Microfluidics deals with the manipulation of small amounts of fluids (in the order of few micro- to pico-liters) and finds a broad application in (bio-)chemistry, biology, pharmacology, and food industries. Most prominently known as Lab-on-a-Chip (LoC), corresponding devices minimize, integrate, automate, and parallelize typical lab operations such as mixing, heating, incubation, etc. on a single device. In order to implement a microfluidic device, droplet microfluidic networks provide a well-established and highly potential platform because droplets are especially suited to encapsulate biological samples like cells, proteins, or DNA. In this platform, the droplets are injected in a continuous, immiscible phase and flow through closed microchannels to modules executing operations on the droplets— eventually realizing a (bio-)chemical experiment. However, when designing a droplet microfluidic network implementing the required operations, a huge number of physical parameters need to be considered (e.g., the dimensions of the channels, flow rates, the applied phases, etc.), which all depend on and affect each other.
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