Determination of Eight Benzoylurea Insecticides in High-Fat Foodstuff Samples by Gel Permeation Chromatography Followed
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Determination of Eight Benzoylurea Insecticides in High-Fat Foodstuff Samples by Gel Permeation Chromatography Followed by High-Performance Liquid Chromatography-Tandem Mass Spectrometry Jingjing Wang 1,2 & Tingting Zhang 1 & Zhiguo Gong 2 & Yun Gao 3 & Jide Wang 1 Yi Zhang 4
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Received: 20 December 2016 / Accepted: 9 March 2017 # Springer Science+Business Media New York 2017
Abstract It is rather challengeable to extract hydrophobic pesticides from the complicated matrices which contain relatively high fatty compounds and ensure high recoveries of target analytes and low levels of coextracted. This paper introduces a simple, quick, and sensitive method for the determination of eight benzoylurea insecticides (BUs) in nuts via gel permeation chromatography (GPC) cleanup coupled with high-performance liquid chromatography-tandem mass spectrometry (LC–MS/MS). By this method, no significant matrix effects were observed. Calibration curves for eight BUs showed good linearity in the range of 10.0 to 500.0 μg kg−1 with correlation coefficients in excess of 0.9990. Meanwhile, recoveries of them were between 82.8 and 113.2% with relative standard derivations lower than 11% at three spiked concentration levels in real samples in walnut, badam, and sweet almond. Limits of quantification were ranged from 1.8 to 9.7 μg kg−1. It proved that the proposed analytical method can be promising technique for the simultaneous determination of multihydrophobic pesticides in nut and other foodstuff samples with high fat content.
* Jide Wang [email protected]
1
Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, Chemistry and Chemical Engineering of Xinjiang University, Urumqi, China
2
Technical Center of Xinjiang Entry-Exit Inspection and Quarantine Bureau, Urumqi, China
3
Xinjiang Changji Environmental Monitoring Center Station, Changji, China
4
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China
Keywords Benzoylurea insecticides . High-fat foodstuff samples . Gel permeation chromatography . High-performance liquid chromatography-tandem mass spectrometry
Introduction Benzoylurea insecticides (BUs) is a class of pesticides that can interfere with the synthesis of chitin in the insect’s cuticle to stop the molting process (Chen et al. 2014). Through inhibiting the biological activity of the endocrines in insect systems, BUs can effectively prevent and eradicate the growth of target insects (Hsiao et al. 2013). Nowadays, it acted as a major pest control reagent and was the third pesticide consumption in the world. Generally, BUs is used during cultivation and storage of nut because of its low toxicity and the favorable effect. Although it has relatively low mammalian toxicity, the massive consumption of BUs on agrochemical could lead to a big risk to human health (Mei et al. 2015). Till now, many countries and organizations have harmonized the maximum residue limits (MRLs) of the BUs (Holt et al. 2015). For example, Japan gove
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