Determination of the isotopic composition of lutetium using MC-ICPMS
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RESEARCH PAPER
Determination of the isotopic composition of lutetium using MC-ICPMS Juan He 1,2 & Juris Meija 1 & Xiandeng Hou 3 & Chengbin Zheng 4 & Zoltán Mester 1 & Lu Yang 1 Received: 18 September 2019 / Revised: 31 October 2019 / Accepted: 8 November 2019 # Crown 2019
Abstract In this study, we report the first independent measurements of lutetium isotopic composition using multi-collector ICPMS in four commercial lutetium materials, including a new NRC candidate lutetium isotopic reference material, LUIS-1. The regression model was used to correct for the instrumental isotopic fractionation (mass bias) using NIST SRM 989 isotopic rhenium as the primary calibrator. The regression model is based on a short 15-min measurement sessions at varying ICP plasma power. Isotope ratio of R176/175 = 0.026553(11)k = 1, corresponding isotopic abundances of x176 = 0.025866(11)k = 1, x175 = 0.974134(11)k = 1, and an atomic weight of Ar(Lu) = 174.966693(13)k = 1 were obtained for lutetium in LUIS-1. Uncertainty estimation was performed using a mixture of modeling approaches in accordance with the JCGM 100:2008 “Guide to the Expression of Uncertainty in Measurement” and its Supplement 1. The relative contribution of the rhenium primary standard to the combined uncertainty of 176 Lu/175Lu isotope ratio was 15%. Keywords MC-ICPMS . Isotope ratio . Isotopic fractionation/mass bias . Regression model . Isotopic abundances . Atomic weight
Introduction Lutetium is one of the lanthanide elements and has a single stable isotope (175Lu) and long-lived radioactive isotope (176Lu), with relative abundances of 97.41% and 2.59%, respectively [1]. The β-decay of 176Lu to 176Hf (t1/2 ≈ 4 × 1010 years) makes the 176Lu–176Hf radiogenic isotopic system a useful chronometer [2–5]. In addition, the lutetium–hafnium isotopic record has played an important role in understanding the crustal evolution processes [6, 7]. Lutetium isotopes also Published in the topical collection featuring Female Role Models in Analytical Chemistry. * Lu Yang [email protected] 1
National Research Council Canada, 1200 Montreal Rd, Ottawa, Ontario K1A 0R6, Canada
2
College of Chemistry, Sichuan University, Chengdu 610064, China
3
Analytical & Testing Center, Sichuan University, 29 Wangjiang Rd, Chengdu 610064, Sichuan, China
4
Key Laboratory of Green Chemistry and Technology of MOE College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China
show important clinical applications. In 1960, Anderson et al. reported the first clinical use of 177Lu for the treatment of myelomatosis [8]. Since then, the application of Lu isotopes in radiopharmaceutical therapy has developed significantly [9]. Furthermore, research in Lu-based materials has grown significantly in recent years. For example, owing to its high thermal conductivity and high density, Lu2O3 is used in highpower lasers and scintillators [10]. Thermal ionization mass spectrometry (TIMS) has been traditionally used to determine isotopic composition of lutetium [11]. Recent years have witnessed
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