Development of a 225 Ac/ 213 Bi Generator with Two Inorganic Sorbents. Processes Involving Radionuclides of the 225 Ac S
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lopment of a 225Ac/213Bi Generator with Two Inorganic Sorbents. Processes Involving Radionuclides of the 225Ac Subfamily N. D. Betenekova,†, S. V. Ermolaevb,*, and A. K. Skasyrskayab a
Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, 620002 Russia b Institute for Nuclear Research of Russian Academy of Sciences, Moscow, 117312 Russia *e-mail: [email protected] Received May 21, 2019; revised May 21, 2019; accepted July 22, 2019
Abstract—Scheme of a two-column 225Ac/213Bi generator using inorganic sorbents based on hydrated titanium oxide (JSC “Termoxid”) and hydrated zirconium oxide modified with nickel-potassium ferrocyanide (Termoxid, T-35) is suggested. 213Bi is obtained via a prolonged washing-out of 221Fr from the first column with T-5 sorbent containing 225Ac and its retention in the second column with T-35 for the decay and accumulation of 213Bi, which is extracted afterwards with a 1 M HCl solution. The direct-flow and circulatory schemes were tested, and the properties of the generator toward radionuclides of the 225Ac subfamily were determined in a wide range of flow rates and eluent volumes. It is assumed that the sorbents of the T-5 and T-35 brands are suitable for creating a 225Ac/213Bi generator with activity of hundreds of 225Ac mCi. Keywords: 225Ac/213Bi generator, inorganic sorbents, titanium and zirconium hydroxides, nickel-potassium ferrocyanide, sorption, desorption, radiation stability DOI: 10.1134/S1066362220040098
EXPERIMENTAL
225Ac/213Bi
generators are promising for repetitively obtaining which finds increasingly wide use in the therapy of oncological diseases [1]. The application of radiation-stable inorganic sorbents can make higher the original activity of the mother 225Ac in generators of this kind to hundreds of mCi. The goal of our study was to examine the modes in which 213Bi is obtained from a prototype 225Ac/213Bi generator constituted by two in-series connected chromatographic columns filled with sorbents of two types, T-5 and T-35, following the procedure developed in [2]. 213Bi was obtained in two stages. First, 221Fr was washed out from the first column containing 225Ac and adsorbed in the second column with T-35, where 221Fr decayed and 213Bi accumulated. Further, the accumulated 213Bi was washed from the second column with a small volume of 1 M HCl. We examined the efficiency of 221Fr washing out from columns containing 225Ac: sorbent T-5 and Actinide Resin extraction-chromatographic resin (Triskem Int., France), and obtained dependences on the concentration of the eluent, its flow rate, and column length. 213Bi
We used inorganic and extraction-chromatographic sorbents. The inorganic sorbents were manufactured by joint-stock company “Termoxid” by the sol-gel method [3, 4] The T-5 sorbent based on hydrated titanium oxide was obtained in the form of ~80-μm granules and dried at a temperature of 100°C [brief designation T-5(100)]. The choice of a sorbent and its parameters, aimed to firmly retain 225Ac, was based on the results of [5]. The T-35
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