Developmental Neuropathology
I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth
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Developmental Neuropathology Second Revised and Expanded Edition
With 180 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
REINHARD L. FRIEDE Georg-August -U niversiHit Gottingen Zentrum Neurologische Medizin, Abteilung Neuropathologie Robert-Koch-StraBe 40,3400 Gottingen, FRG
Library of Congress Cataloging-in-Publication Data. Friede, Reinhard L. Developmental neuropathology 1 Reinhard L. Friede. - 2nd rev. and expanded ed. p. cm. Includes bibliographies and index. ISBN-l3: 978-3-642-73699-5
e-ISBN-13: 978-3-642-73697-1
DOI:1O.10071 978-3-642-73697-1 (U.S.: alk. paper): 1. Pediatric neurology. 2. Developmental neurology. 3 Metabolism, Inborn errors of. I. Title. [DNLM: 1. Metabolism, Inborn Errors. 2. Nervous System Diseases - in infancy & childhood. 3. Nervous System Diseases-pathology. WS 340 F899d) RJ486.F691988 618.92'8047-dc19 DNLMlDLC for Library of Congress 88-30874 CIP This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1989
Softcover reprint of the hardcover 2nd edition 1989 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting: Fotosatz & Design, Berchtesgaden
2125/3130-543210 . Printed on acid-free paper
Preface
I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelinopathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the liter
