Diagnostic Neuropathology Volume II
Every year dozens of physicians-in-training face, for the first time, the responsibil ity of examining and diagnosing central nervous system tumors or biopsies of the central nervous system, the peripheral nerves or muscles, whose surgical resection has
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Diagnostic Neuropathology Volume II Editors
Julio H. Garcia, M.D. The University of Alabama at Birmingham, U.S.A.
f ulio Escalona-Zapata, M.D. Universidad Complutense de Madrid, Spain
Uriel Sandbank, M.D. University of Tel-Aviv, Israel
Jorge Cerv6s-Navarro, M.D. Free University, Berlin, F.R.G.
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Springer-Verlag London Ltd.
Copyright © 1990, Springer-Verlag London Originally published by Field & Wood, Medical Publishers, Inc. in 1990 Softcover reprint of the hardcover 1st edition 1990 All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any other information storage and retrieval system, without permission in writing from the Publisher.
ISBN 978-3-662-06587-7 ISBN 978-3-662-06585-3 (eBook) DOI 10.1007/978-3-662-06585-3
Contents
Contributors Preface
vii ix
5 Tissue Culture in the Diagnosis of Brain Tumors J. Escalona-Zapata
3
INTRODUCTION HISTORICAL NOTE LIMITING FACTORS TISSUE CULTURE EVOLUTION PATTERNS OF GROWTH Tumors of Neuronal Pattern Tumors of Reticular or Plexiform Pattern Tumors of Epithelial Pattern REFERENCES
3 3 4 4 5 5 7
26 44
6 Brain Biopsy
47
]. H. Garcia and]. Cerv6s-Navarro INTRODUCTION DURA MATER LEPTOMENINGES BLOOD VESSELS: ARTERIAL, VENOUS, AND CAPILLARY CEREBRAL AND CEREBELLAR CORTICES WHITE MATTER ABNORMALITIES REFERENCES
47
50 51 57 64
96
116
v
vi
Contents
7 Nerve Biopsy
123
Thomas W. Bouldin INTRODUCTION HANDLING THE SURAL NERVE SPECIMEN NORMAL HISTOLOGY OF SURAL NERVE NONSPECIFIC STRUCTURAL CHANGES IN PERIPHERAL NERVE TYPES OF PERIPHERAL NEUROPATHIES PATHOLOGIC CHANGES ASSOCIATED WITH SPECIFIC NEUROPATHIES TUMORS OF THE NERVE SHEATH REFERENCES
123 123 125
131 144 145 175
192
8 Muscle Biopsy
203
Hans H. Goebel INTRODUCTION NORMAL MORPHOLOGIC APPEARANCES NONSPECIFIC STRUCTURAL CHANGES CLASSIFICATION OF NEUROMUSCULAR DISORDERS MUSCULAR DYSTROPHIES NEUROGENIC ATROPHIES CONGENITAL MYOPATHIES INFLAMMATORY MYOPATHIES AND COLLAGEN VASCULAR DISEASES METABOLIC MYOPATHIES MYASTHENIA GRAVIS AND MYASTHENIC SYNDROMES MYOTONIAS OCULAR MYOPATHIES MISCELLANEOUS ACKNOWLEDGMENTS REFERENCES
Index
203 206 209 229
230 239 245 256 263
273 274
279 282
282 282
291
Contributors
Thomas W. Bouldin, M.D. Associate Professor of Pathology University of North Carolina Chapel Hill, North Carolina, USA
J. Cerv6s-Navarro, M.D.
Professor of Neuropathology and Director Institute of Neuropathology Klinikum Steglitz, Freie UniversWi.t
Berlin, Federal Republic of Germany
J. H. Garcia, M.D.
Professor of Pathology University of Alabama at Birmingham Birmingham, Alabama, USA
Hans H. Goebel, M.D. Professor of Neuropathology Johannes Gutenberg Universitat Mainz, Federal Republic of Germany
f. Escalona-Zapata, M.D.
Professor of Pathology and Director Department of Anatomical Pathology Hospital Provincial Madrid, Spain
vii
Preface
Every year dozens of physicians-in-training face, for the first time, the responsibility of examining and diagnosing central nervous syst
