Dexmedetomidine
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Dexmedetomidine Polyuria and hypernatraemia: case report A 67-year-old man developed polyuria and hypernatraemia while receiving dexmedetomidine for management of alcohol withdrawal. The man presented to our Emergency Department with a new onset seizure. His hospital stay was complicated by acute respiratory failure secondary to pneumonia. Treatment with propofol was switched to dexmedetomidine [dosage and route not stated] for management of alcohol withdrawal. On the next day, he was found to have serum sodium of 154 mEq/L associated with increasing urine output and urine osmolality. Initially, free water replacement was attempted. However, serum sodium failed to respond to therapy. Following treatment with desmopressin, an appropriate physiologic response was noted. The man was transitioned to propofol and showed significant improvement in hypernatraemia and polyuria within 24 hours. The following day, a complete resolution was noted. Author comment: "We report a unique case of dexmedetomidine induced polyuria where hypernatremia and polyuria was observed within 24 hours of administration of dexmedetomidine. . ." Chow P, et al. A case report of dexmedetomidineinduced polyuria and review of literature. Critical Care Medicine 47 (Suppl. 1): p626, No. 1, Jan 2019. Available from: URL: http://doi.org/10.1097/01.ccm.0000552044.51504.d4 [abstract] 803431862 USA
0114-9954/19/1778-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 9 Nov 2019 No. 1778
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