Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis
- PDF / 1,155,694 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 96 Downloads / 146 Views
ORIGINAL ARTICLE
Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis Vanessa Sandri1 • Itamar Luı´s Gonc¸alves2 Marisa Lucia Romani Paraboni1,3
•
Gustavo Machado das Neves2
•
Received: 9 June 2020 / Accepted: 17 August 2020 Ó Indian Society for Parasitology 2020
Abstract Toxoplasmosis is a zoonosis caused by Toxoplasma gondii, which can be acquired by oral contact and may cause severe health problems especially for pregnant (congenital toxoplasmosis) and immunocompromised patients. This study aimed to verify the diagnostic significance of hematological parameters and C-reactive protein (CRP) for toxoplasmosis acute detection. A case-control study was carried out between December 2017 and May 2018, in samples of convenience independent of age and sex. The case group was formed by 25 patients with positive anti-Toxoplasma gondii IgG/IgM antibody and the control group was formed by 21 patients with non-positive anti-Toxoplasma gondii IgG/IgM antibody. The results of the hematological parameters and CRP were analyzed in these patients. The patients with Toxoplasma gondii IgM antibody reagent showed higher lymphocytes counting and lower neutrophils counting than the control group. C-reactive protein levels were not different between the groups case and control. ROC curve analysis highlighted that the cut-off value of [ 32.00% for lymphocytes and \ 57.50% for neutrophils were able to produce specificity higher than 90% for IgM antibody detection. The Naı¨ve Bayes classifier was considered suitable (AUC & 0.700)
& Itamar Luı´s Gonc¸alves [email protected] 1
Faculty of Pharmacy, Universidade Regional Integrada do Alto Uruguai e das Misso˜es - Erechim, Sete de Setembro Avenue, 1621, Erechim, RS 99709-910, Brazil
2
Programa de Po´s-Graduac¸a˜o em Cieˆncias Farmaceˆuticas, Universidade Federal do Rio Grande do Sul, Ipiranga Avenue 2752, Porto Alegre, RS 90610-000, Brazil
3
Department of Ophthalmology, Universidade Federal de Sa˜o Paulo, Botucatu Street, 821, Sa˜o Paulo, SP 4023-062, Brazil
to separate both groups according to their white cell counting. Changes in lymphocytes and neutrophils may be useful parameters for toxoplasmosis identification and may be used as a tool in the complementary diagnosis of toxoplasmosis. Graphic abstract
Keywords Toxoplasmosis Complementary diagnosis Hematological profile IgG IgM
Introduction Toxoplasmosis is a zoonosis caused by Toxoplasma gondii, an intracellular parasite that is the unique specie able to produce the disease in all the hosts (Aguirre et al. 2019). Toxoplasmosis is acquired by oral contact with infecting
123
J Parasit Dis
forms eliminated in feline feces, who contaminate the soil and the water (Escotte-Binet et al. 2019). The ingestion of raw or undercook meat contaminated with parasite cysts is an important way of acquiring the disease (Paraboni et al. 2019; Sroka et al. 2020), while the congenital transmission is also extensively reported and represents a public health problem (de Melo et al. 20
Data Loading...
