Diagnostic Test Accuracy Studies in Dementia A Pragmatic Approach
The new and updated edition of this book explains the key steps in planning and executing diagnostic test accuracy studies in dementia, serving as an introduction to the topic with clear explanations of difficulties and pitfalls. It has been fully r
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Diagnostic Test Accuracy Studies in Dementia
A. J. Larner
Diagnostic Test Accuracy Studies in Dementia A Pragmatic Approach Second Edition
A. J. Larner Walton Centre for Neurology and Neurosurgery Liverpool, UK
ISBN 978-3-030-17561-0 ISBN 978-3-030-17562-7 (eBook) https://doi.org/10.1007/978-3-030-17562-7 © Springer Nature Switzerland AG 2015, 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To Martin Loyal cousin (and supporter of Gloucestershire County Cricket Club) and dedicated healthcare professional
Preface to the First Edition
This book has evolved from more than a decade of personal experience in conducting diagnostic test accuracy studies of clinical signs and cognitive and non-cognitive screening instruments in a dedicated cognitive disorders clinic. Many of these studies have been published, and are summarised elsewhere (Larner 2014a, b). The ageing of the human population with the consequent increase in numbers of individuals afflicted with cognitive impairment and dementia mandates diagnostic test accuracy studies to identify and eventually treat these patients effectively. If, as seems likely, population based testing for early identification becomes the future policy norm, the requirement for tests with established high diagnostic test accuracy is self-evident. A rigorous methodology developed to generate meaningful data from such studies is therefore an imperative need. As well as giving a general overview, the book gives particular emphasis to, and argues in favour of, what I have previously termed “pragmatic diagnostic accuracy studies” (Larner 2012a, 2014a, pp. 33–5). This methodology seems to me to correspond largely with Sackett and Haynes’ (2002
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