Didymotic Skin Disorders
In the group of didymotic genodermatoses we can distinguish allelic from non-allelic twin spotting. Molecular proof is so far lacking but it is very likely that the concept will be confirmed in the proposed examples of allelic didymosis such as the paired
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Mosaicism in Human Skin Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia
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Mosaicism in Human Skin
Rudolf Happle
Mosaicism in Human Skin Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia
Rudolf Happle Department of Dermatology Freiburg University Medical Center Freiburg Germany
ISBN 978-3-642-38764-7 ISBN 978-3-642-38765-4 DOI 10.1007/978-3-642-38765-4 Springer Heidelberg New York Dordrecht London
(eBook)
Library of Congress Control Number: 2013951144 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During my training in dermatology in the years 1968 through 1972, I had seen some linear skin lesions but never heard or read of Alfred Blaschko since, among dermatologists, his lines had fallen into oblivion. Shortly thereafter, when I worked at the University of Münster, the geneticist Rudolf Pfeiffer told me of Blaschko’s atlas and how to find this book. I was fascinated by Blaschko’s innovating ideas and clarity of writing. Some years later, I began to give lectures on possible genetic mechanisms giving rise to this system of lines. In part my proposed explanations were influenced by some seminal thoughts that I had found in the book Medical Genetics written by Widukind
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