Differentiating atypical hemangiomas and vertebral metastases: a field-of-view (FOV) and FOCUS intravoxel incoherent mot
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ORIGINAL ARTICLE
Differentiating atypical hemangiomas and vertebral metastases: a field‑of‑view (FOV) and FOCUS intravoxel incoherent motion (IVIM) diffusion‑weighted imaging (DWI) study Jibin Cao1 · Sijia Gao1 · Chenying Zhang1 · Yinxia Zhang2 · Wenge Sun1 · Lingling Cui1 Received: 1 July 2020 / Revised: 15 September 2020 / Accepted: 7 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Some atypical vertebral hemangiomas (VHs) may mimic metastases on routine MRI and can result in misdiagnosis and ultimately to additional imaging, biopsy and unnecessary costs. The purpose of this study is to assess the utility of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) on account of field-of-view optimized and constrained undistorted single shot (FOCUS) in distinguishing atypical VHs and vertebral metastases. Methods A total of 25 patients with vertebral metastases and 25 patients with atypical VHs were confirmed by clinical follow-up or pathology. IVIM-DWI imaging was performed at different b values (0, 30, 50, 100, 150, 200, 400, 600, 800, 1000 mm2/s). IVIM parameters [the true diffusion coefficient (D), pseudodiffusion coefficient (D*), standard apparent diffusion coefficient (ADC), and perfusion fraction (f)] were calculated and compared between two groups by using Student’s t test. A receiver operating characteristic analysis was performed. Results Quantitative analysis of standard ADC and D parameters showed significantly lower values in vertebral metastases when compared to atypical hemangiomas [ADC value: (0.70 ± 0.12) × 10–3 mm2/s vs (1.14 ± 0.28) × 10–3 mm2/s; D value: (0.47 ± 0.07) × 10–3 mm2/s vs (0.76 ± 0.14) × 10–3 mm2/s, all P
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