Diffuse tensor imaging of lower extremities: a novel MR imaging technique for chemotherapy-induced peripheral neuropathy
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CLINICAL TRIAL
Diffuse tensor imaging of lower extremities: a novel MR imaging technique for chemotherapy‑induced peripheral neuropathy Pavani Chalasani1,2 · Mihra Taljanovic3 · Jenn Segar1,2 · Kiah Farr4 · Hninyee Win1 · Betsy C. Wertheim2 · Michele Chu‑Pilli2 · Sima Ehsani1,2 · Denise J. Roe2,5 · Lana Gimber6 Received: 29 July 2020 / Accepted: 18 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Chemotherapy-induced peripheral neuropathy (CIPN) is caused by drug-induced damage to the axons which is not detected easily due to lack of reliable, clinically applicable modalities. Diffuse tensor imaging (DTI) allows for quantitative measurements of fractional anisotropy (FA) and apparent diffusion coefficient (ADC), which have been shown to detect nerve injury by Magnetic Resonance Imaging (MRI). Methods We sought to evaluate if DTI could be used for detection of CIPN in patients with breast cancer treated with a taxane. Patients with h/o exposure to neurotoxic chemotherapy, diabetes, or peripheral neuropathy were excluded. Patients completed pre- and post-chemotherapy MRI of bilateral legs and FACT&GOG-Ntx. Genotyping of single-nucleotide variations (SNVs) was performed to detect known associations with CIPN. Results We had 14 evaluable patients in this prospective trial. Mean FA values post-chemotherapy were significantly lower than baseline at mid-calf (p
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