Digital Versus Optical Diagnosis of Follicular Patterned Thyroid Lesions
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ORIGINAL PAPER
Digital Versus Optical Diagnosis of Follicular Patterned Thyroid Lesions Ayat Aloqaily1,2 · Antonio Polonia1,5 · Sofia Campelos1 · Nusaiba Alrefae1,3 · Joao Vale1 · Ana Caramelo1 · Catarina Eloy1,4,5 Received: 2 September 2020 / Accepted: 21 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objectives To study the concordance between pathologists in the diagnosis of follicular patterned thyroid lesions using both digital and conventional optical settings. Material and Methods Five pathologists reviewed 50 hematoxylin and eosin-stained slides of follicular patterned thyroid lesions using both digital (the D-Sight 2.0 scanner and navigator viewer) and conventional optical instruments with washout interval time. Results The mean concordance rate with the ground truth (GT) was similar between conventional optical and digital observation (83.2 and 85.2%, respectively). The most frequent reason for diagnostic discordance with GT on both systems was the evaluation of nuclear features (69.1% for conventional optical observation and 59.4% for digital observation). The intraobserver diagnostic concordance mean was 86.8%. Time for digital observation (mean time per case = 2.9 ± 0.8 min) was higher than that for conventional optical observation (mean time per case = 2.0 ± 0.7 min). Interobserver correlation of measurements was higher in the digital observation than the conventional optical observation. Conclusion Conventional optical and digital observation settings showed a comparable accuracy for the diagnosis of follicular patterned thyroid nodules, as well as substantial intraobserver agreement and a significant improvement in the reproducibility of the measurements that support the use of digital diagnosis in thyroid pathology. The origins underlying the variability of the diagnosis were the same in both conventional optical microscopy and digital pathology systems. Keywords Digital pathology · Papillary thyroid carcinoma · Noninvasive follicular thyroid neoplasm with papillary-like nuclear features · Thyroid · Thyroid cancer
Introduction Digital systems in the pathologist workstation offer a different environment for evaluation and reporting in comparison with the one provided in the setting of traditional optical microscopy. The benefit of having a digital pathology * Ayat Aloqaily [email protected] 1
Institute of Molecular Pathology and Immunology, Ipatimup Diagnostics, University of Porto (IPATIMUP)/i3S, Rua Júlio Amaral de Carvalho 45, 4200‑135 Porto, Portugal
2
King Abdullah University Hospital (KAUH), Jordan, University of Science and Technology (JUST), Irbid, Jordan
3
Kuwait Institute for Medical Specializations, Kuwait, Kuwait
4
Medical Faculty, Porto University, Porto, Portugal
5
Instituto de Investigação E Inovação Em Saúde (i3S), University of Porto, Porto, Portugal
workflow classically includes better ergonomics, immediate access to archive slides, distance reporting, and consultations [1]. Pathologists are still discov
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