Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studie
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ORIGINAL ARTICLE
Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies W. F. Vaz1,2 · J. M. F. Custodio3 · G. D. C. D’Oliveira3 · B. J. Neves4 · P. S. C. Junior5 · J. T. M. Filho3 · C. H. Andrade4 · C. N. Perez3 · E. P. Silveira‑Lacerda6 · H. B. Napolitano1 Received: 31 August 2019 / Accepted: 5 December 2019 © Springer Nature Switzerland AG 2020
Abstract Cancer is one of the leading causes of death worldwide and requires intense and growing research investments from the public and private sectors. This is expected to lead to the development of new medicines. A determining factor in this process is the structural understanding of molecules with potential anticancer properties. Since the major compounds used in cancer therapies fail to encompass every spectrum of this disease, there is a clear need to research new molecules for this purpose. As it follows, we have studied the class of quinolinones that seem effective for such therapy. This paper describes the structural elucidation of a novel dihydroquinoline by single-crystal X-ray diffraction and spectroscopy characterization. Topology studies were carried through Hirshfeld surfaces analysis and molecular electrostatic potential map; electronic stability was evaluated from the calculated energy of frontier molecular orbitals. Additionally, in silico studies by molecular docking indicated that this dihydroquinoline could act as an anticancer agent due to their higher binding affinity with human aldehyde dehydrogenase 1A1 (ALDH 1A1). Tests in vitro were performed for VERO (normal human skin keratinocytes), B16F10 (mouse melanoma), and MDA-MB-231 (metastatic breast adenocarcinoma), and the results certified that compound as a potential anticancer agent. Graphic abstract A Dihydroquinoline derivative was tested against three cancer cell lines and the results attest that compound as potential anticancer agent.
Keywords X-ray diffraction · Molecular docking · ADMET properties · Hirshfeld surface · Anticancer activity
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11030-019-10024-x) contains supplementary material, which is available to authorized users. * W. F. Vaz [email protected] Extended author information available on the last page of the article
Compounds derived from the fusion of two molecules acting independently can increase the pharmacological effectiveness, comparing to the sum of each individual moiety’s potencies. These compounds can involve various functional parts, including small molecules or biomolecules, acting either simultaneously or sequentially [1]. In this paper, our
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purpose was to study a novel hybrid compound composed by chalcone, sulfonamide, and quinolinone moieties. Chemically, chalcones provide a backbone with two aromatic rings linked by both carbonyl and olefin portions, being this molecular structure responsible by their biological potential [2–5]. In contrast, benzene
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